TY - JOUR
T1 - Role of dendretic cells in Th1/Th2 balance
T2 - A novel therapeutic target of allergic diseases
AU - Ohshima, Yusei
AU - Yasutomi, Motoko
AU - Omata, Nemuko
AU - Mayumi, Mitsufumi
PY - 2004/9
Y1 - 2004/9
N2 - Considerable evidence supports the role of dendritic cells (DC) in the pathogenesis of allergic diseases. Dendritic cells, as the most potent antigen-presenting cells (APC) for the induction of primary immune response to antigen, are deeply involved in the differentiation of naïve T cells into Th2 cells, thereby developing the development of allergic sensitization. After sensitization, DC may also function as a major APC to control the activation and clonal expansion of memory Th2 cells. In addition, DC are able to produce chemokines to recruit Th2 cells into inflammatory sites, indicating DC are important agents in various phases of allergic inflammation. Recently, we have demonstrated that monocyte chemotactic protein-1 not only regulates the homing of DC, but also modulates DC function. The present paper reviews the role of DC in the regulation of the Th2 response in allergic diseases and discusses the possibility of a new therapeutic strategy targeting chemokine-mediated regulation of DC function.
AB - Considerable evidence supports the role of dendritic cells (DC) in the pathogenesis of allergic diseases. Dendritic cells, as the most potent antigen-presenting cells (APC) for the induction of primary immune response to antigen, are deeply involved in the differentiation of naïve T cells into Th2 cells, thereby developing the development of allergic sensitization. After sensitization, DC may also function as a major APC to control the activation and clonal expansion of memory Th2 cells. In addition, DC are able to produce chemokines to recruit Th2 cells into inflammatory sites, indicating DC are important agents in various phases of allergic inflammation. Recently, we have demonstrated that monocyte chemotactic protein-1 not only regulates the homing of DC, but also modulates DC function. The present paper reviews the role of DC in the regulation of the Th2 response in allergic diseases and discusses the possibility of a new therapeutic strategy targeting chemokine-mediated regulation of DC function.
KW - Dendritic cell
KW - Monocyte chemotactic protein-1
KW - OX40 ligand
KW - Regulatory T cells
KW - Th2
UR - https://www.scopus.com/pages/publications/4744359622
U2 - 10.1111/j.1440-1592.2004.00337.x
DO - 10.1111/j.1440-1592.2004.00337.x
M3 - Review article
AN - SCOPUS:4744359622
SN - 1323-8930
VL - 53
SP - 219
EP - 226
JO - Allergology International
JF - Allergology International
IS - 3
ER -