Abstract
Many cells develop contractile actin-myosin bundles, i.e. stress fibers, when cultured on stiff but not on soft substrates, suggesting an important role of cytoskeletal tension in stress fiber formation. To further examine this issue, we cultured human aortic endothelial cells (HAECs) overnight on an elastic substrate pre-stretched in one direction. It was shown that stress fiber integrity is strongly dependent on the presence of cytoskeletal tension.
| Original language | English |
|---|---|
| Pages (from-to) | S-65 |
| Journal | Annals of Biomedical Engineering |
| Volume | 28 |
| Issue number | SUPPL. 1 |
| State | Published - 2000 |
| Externally published | Yes |
| Event | 2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: 12 Oct 2000 → 14 Oct 2000 |