Role of catecholamine degradative enzymes and the adrenergic innervation in determining the cerebrovascular response to infused norepinephrine

T. A. McCalden, A. D. Mendelow, Anne Coull, D. R.L. Scriven, C. Rosendorff, B. H. Eldelman

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7 Scopus citations

Abstract

Cerebral blood flow responses to intra-arterial infusion of norepinephrine (NE) at 0.55 μg/kg/m in and 1.1 μg/kg/min were studied in 3 groups of baboons. The flow was measured by the in-tracarotid 139xenon clearance technique using a computer program to calculate flow (height over area - H/A) flow (initial slope - is) and cerebral metabolic utilization of oxygen (CMRO2). The normal response to NE was to increase flow without significant changes in CMRO2. Blockade of catechol-o-methyl transferase (COMT) produced vasoconstrictor responses to these same NE doses. Monoamine oxidase blockade abolished the normal vasodilation. Denervation of the cerebral circulation with intracisternal 6-hydroxydopamine produced vasoconstrictor responses with flow (H/A) but not with flow (is). It is concluded that the extraneuronal COMT enzyme is important in limiting the access of blood-borne NE to cerebrovascular constrictor receptors.

Original languageEnglish
Pages (from-to)319-322
Number of pages4
JournalStroke
Volume10
Issue number3
DOIs
StatePublished - 1979
Externally publishedYes

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