Role of catecholamine degradative enzymes and the adrenergic innervation in determining the cerebrovascular response to infused norepinephrine

T. A. McCalden; A. D. Mendelow; Anne Coull; D. R.L. Scriven; C. Rosendorff; B. H. Eldelman

doi:10.1161/01.STR.10.3.319

Role of catecholamine degradative enzymes and the adrenergic innervation in determining the cerebrovascular response to infused norepinephrine

T. A. McCalden, A. D. Mendelow, Anne Coull, D. R.L. Scriven, C. Rosendorff, B. H. Eldelman

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cerebral blood flow responses to intra-arterial infusion of norepinephrine (NE) at 0.55 μg/kg/m in and 1.1 μg/kg/min were studied in 3 groups of baboons. The flow was measured by the in-tracarotid ¹³⁹xenon clearance technique using a computer program to calculate flow (height over area - H/A) flow (initial slope - is) and cerebral metabolic utilization of oxygen (CMRO₂). The normal response to NE was to increase flow without significant changes in CMRO₂. Blockade of catechol-o-methyl transferase (COMT) produced vasoconstrictor responses to these same NE doses. Monoamine oxidase blockade abolished the normal vasodilation. Denervation of the cerebral circulation with intracisternal 6-hydroxydopamine produced vasoconstrictor responses with flow (H/A) but not with flow (is). It is concluded that the extraneuronal COMT enzyme is important in limiting the access of blood-borne NE to cerebrovascular constrictor receptors.

Original language	English
Pages (from-to)	319-322
Number of pages	4
Journal	Stroke
Volume	10
Issue number	3
DOIs	https://doi.org/10.1161/01.STR.10.3.319
State	Published - 1979
Externally published	Yes

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title = "Role of catecholamine degradative enzymes and the adrenergic innervation in determining the cerebrovascular response to infused norepinephrine",

abstract = "Cerebral blood flow responses to intra-arterial infusion of norepinephrine (NE) at 0.55 μg/kg/m in and 1.1 μg/kg/min were studied in 3 groups of baboons. The flow was measured by the in-tracarotid 139xenon clearance technique using a computer program to calculate flow (height over area - H/A) flow (initial slope - is) and cerebral metabolic utilization of oxygen (CMRO2). The normal response to NE was to increase flow without significant changes in CMRO2. Blockade of catechol-o-methyl transferase (COMT) produced vasoconstrictor responses to these same NE doses. Monoamine oxidase blockade abolished the normal vasodilation. Denervation of the cerebral circulation with intracisternal 6-hydroxydopamine produced vasoconstrictor responses with flow (H/A) but not with flow (is). It is concluded that the extraneuronal COMT enzyme is important in limiting the access of blood-borne NE to cerebrovascular constrictor receptors.",

author = "McCalden, {T. A.} and Mendelow, {A. D.} and Anne Coull and Scriven, {D. R.L.} and C. Rosendorff and Eldelman, {B. H.}",

year = "1979",

doi = "10.1161/01.STR.10.3.319",

language = "English",

volume = "10",

pages = "319--322",

journal = "Stroke",

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T1 - Role of catecholamine degradative enzymes and the adrenergic innervation in determining the cerebrovascular response to infused norepinephrine

AU - McCalden, T. A.

AU - Mendelow, A. D.

AU - Coull, Anne

AU - Scriven, D. R.L.

AU - Rosendorff, C.

AU - Eldelman, B. H.

PY - 1979

Y1 - 1979

N2 - Cerebral blood flow responses to intra-arterial infusion of norepinephrine (NE) at 0.55 μg/kg/m in and 1.1 μg/kg/min were studied in 3 groups of baboons. The flow was measured by the in-tracarotid 139xenon clearance technique using a computer program to calculate flow (height over area - H/A) flow (initial slope - is) and cerebral metabolic utilization of oxygen (CMRO2). The normal response to NE was to increase flow without significant changes in CMRO2. Blockade of catechol-o-methyl transferase (COMT) produced vasoconstrictor responses to these same NE doses. Monoamine oxidase blockade abolished the normal vasodilation. Denervation of the cerebral circulation with intracisternal 6-hydroxydopamine produced vasoconstrictor responses with flow (H/A) but not with flow (is). It is concluded that the extraneuronal COMT enzyme is important in limiting the access of blood-borne NE to cerebrovascular constrictor receptors.

AB - Cerebral blood flow responses to intra-arterial infusion of norepinephrine (NE) at 0.55 μg/kg/m in and 1.1 μg/kg/min were studied in 3 groups of baboons. The flow was measured by the in-tracarotid 139xenon clearance technique using a computer program to calculate flow (height over area - H/A) flow (initial slope - is) and cerebral metabolic utilization of oxygen (CMRO2). The normal response to NE was to increase flow without significant changes in CMRO2. Blockade of catechol-o-methyl transferase (COMT) produced vasoconstrictor responses to these same NE doses. Monoamine oxidase blockade abolished the normal vasodilation. Denervation of the cerebral circulation with intracisternal 6-hydroxydopamine produced vasoconstrictor responses with flow (H/A) but not with flow (is). It is concluded that the extraneuronal COMT enzyme is important in limiting the access of blood-borne NE to cerebrovascular constrictor receptors.

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JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 3

ER -

Role of catecholamine degradative enzymes and the adrenergic innervation in determining the cerebrovascular response to infused norepinephrine

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