Role of Apoptosis in Adverse Ventricular Remodeling

Antonio Abbate, Jagat Narula

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

Apoptosis is a key feature in the progression of heart disease. Stage B heart failure is characterized by a structurally abnormal heart in which the remodeled myocardium is prone to apoptosis. Elimination of the proapoptotic stimuli or inhibition of the apoptotic cascade could presumably rescue the myocardium and halt the progression of adverse remodeling and heart failure. In this article, the authors review the role of apoptosis (or programmed cell death) in determining the evolution of symptomatic heart failure and particularly the adverse remodeling in the aftermath of acute myocardial infarction.

Original languageEnglish
Pages (from-to)79-86
Number of pages8
JournalHeart Failure Clinics
Volume8
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Apoptosis
  • Caspase
  • Heart failure
  • Ventricular remodeling

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