TY - JOUR
T1 - Role of advanced glycation endproducts and potential therapeutic interventions in dialysis patients
AU - Mallipattu, Sandeep K.
AU - He, John C.
AU - Uribarri, Jaime
PY - 2012/9
Y1 - 2012/9
N2 - It has been nearly 100years since the first published report of advanced glycation end products (AGEs) by the French chemist Maillard. Since then, our understanding of AGEs in diseased states has dramatically changed. Especially in the last 25years, AGEs have been implicated in complications related to aging, neurodegenerative diseases, diabetes, and chronic kidney disease. Although AGE formation has been well characterized by both in vitro and in vivo studies, few prospective human studies exist demonstrating the role of AGEs in patients on chronic renal replacement therapy. As the prevalence of end-stage renal disease (ESRD) in the United States rises, it is essential to identify therapeutic strategies that either delay progression to ESRD or improve morbidity and mortality in this population. This article reviews the role of AGEs, especially those of dietary origin, in ESRD patients as well as potential therapeutic anti-AGE strategies in this population.
AB - It has been nearly 100years since the first published report of advanced glycation end products (AGEs) by the French chemist Maillard. Since then, our understanding of AGEs in diseased states has dramatically changed. Especially in the last 25years, AGEs have been implicated in complications related to aging, neurodegenerative diseases, diabetes, and chronic kidney disease. Although AGE formation has been well characterized by both in vitro and in vivo studies, few prospective human studies exist demonstrating the role of AGEs in patients on chronic renal replacement therapy. As the prevalence of end-stage renal disease (ESRD) in the United States rises, it is essential to identify therapeutic strategies that either delay progression to ESRD or improve morbidity and mortality in this population. This article reviews the role of AGEs, especially those of dietary origin, in ESRD patients as well as potential therapeutic anti-AGE strategies in this population.
UR - https://www.scopus.com/pages/publications/84866549194
U2 - 10.1111/j.1525-139X.2012.01081.x
DO - 10.1111/j.1525-139X.2012.01081.x
M3 - Article
C2 - 22548330
AN - SCOPUS:84866549194
SN - 0894-0959
VL - 25
SP - 529
EP - 538
JO - Seminars in Dialysis
JF - Seminars in Dialysis
IS - 5
ER -