Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Ania Wajnberg; Fatima Amanat; Adolfo Firpo; Deena R. Altman; Mark J. Bailey; Mayce Mansour; Meagan McMahon; Philip Meade; Damodara Rao Mendu; Kimberly Muellers; Daniel Stadlbauer; Kimberly Stone; Shirin Strohmeier; Viviana Simon; Judith Aberg; David L. Reich; Florian Krammer; Carlos Cordon-Cardo

doi:10.1126/science.abd7728

Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

Ania Wajnberg, Fatima Amanat, Adolfo Firpo, Deena R. Altman, Mark J. Bailey, Mayce Mansour, Meagan McMahon, Philip Meade, Damodara Rao Mendu, Kimberly Muellers, Daniel Stadlbauer, Kimberly Stone, Shirin Strohmeier, Viviana Simon, Judith Aberg, David L. Reich, Florian Krammer, Carlos Cordon-Cardo

Research output: Contribution to journal › Article › peer-review

849 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggest that more than 90% of seroconverters make detectable neutralizing antibody responses. These titers remain relatively stable for several months after infection.

Original language	English
Pages (from-to)	1227-1230
Number of pages	4
Journal	Science
Volume	370
Issue number	6521
DOIs	https://doi.org/10.1126/science.abd7728
State	Published - 4 Dec 2020

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Wajnberg, A., Amanat, F., Firpo, A., Altman, D. R., Bailey, M. J., Mansour, M., McMahon, M., Meade, P., Mendu, D. R., Muellers, K., Stadlbauer, D., Stone, K., Strohmeier, S., Simon, V., Aberg, J., Reich, D. L., Krammer, F., & Cordon-Cardo, C. (2020). Robust neutralizing antibodies to SARS-CoV-2 infection persist for months. Science, 370(6521), 1227-1230. https://doi.org/10.1126/science.abd7728

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title = "Robust neutralizing antibodies to SARS-CoV-2 infection persist for months",

abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggest that more than 90% of seroconverters make detectable neutralizing antibody responses. These titers remain relatively stable for several months after infection.",

author = "Ania Wajnberg and Fatima Amanat and Adolfo Firpo and Altman, {Deena R.} and Bailey, {Mark J.} and Mayce Mansour and Meagan McMahon and Philip Meade and Mendu, {Damodara Rao} and Kimberly Muellers and Daniel Stadlbauer and Kimberly Stone and Shirin Strohmeier and Viviana Simon and Judith Aberg and Reich, {David L.} and Florian Krammer and Carlos Cordon-Cardo",

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doi = "10.1126/science.abd7728",

language = "English",

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Wajnberg, A, Amanat, F, Firpo, A, Altman, DR, Bailey, MJ, Mansour, M, McMahon, M, Meade, P, Mendu, DR, Muellers, K, Stadlbauer, D, Stone, K, Strohmeier, S, Simon, V , Aberg, J , Reich, DL, Krammer, F & Cordon-Cardo, C 2020, 'Robust neutralizing antibodies to SARS-CoV-2 infection persist for months', Science, vol. 370, no. 6521, pp. 1227-1230. https://doi.org/10.1126/science.abd7728

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AU - Wajnberg, Ania

AU - Amanat, Fatima

AU - Firpo, Adolfo

AU - Altman, Deena R.

AU - Bailey, Mark J.

AU - Mansour, Mayce

AU - McMahon, Meagan

AU - Meade, Philip

AU - Mendu, Damodara Rao

AU - Muellers, Kimberly

AU - Stadlbauer, Daniel

AU - Stone, Kimberly

AU - Strohmeier, Shirin

AU - Simon, Viviana

AU - Aberg, Judith

AU - Reich, David L.

AU - Krammer, Florian

AU - Cordon-Cardo, Carlos

PY - 2020/12/4

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AB - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global pandemic with millions infected and more than 1 million fatalities. Questions regarding the robustness, functionality, and longevity of the antibody response to the virus remain unanswered. Here, on the basis of a dataset of 30,082 individuals screened at Mount Sinai Health System in New York City, we report that the vast majority of infected individuals with mild-to-moderate COVID-19 experience robust immunoglobulin G antibody responses against the viral spike protein. We also show that titers are relatively stable for at least a period of about 5 months and that anti-spike binding titers significantly correlate with neutralization of authentic SARS-CoV-2. Our data suggest that more than 90% of seroconverters make detectable neutralizing antibody responses. These titers remain relatively stable for several months after infection.

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Robust neutralizing antibodies to SARS-CoV-2 infection persist for months

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