Robertsonian translocation studies on the significance of Trisomy 15 in murine T-cell leukemia

Jack Spira; Francis Wiener; George Klein

doi:10.1016/0165-4608(83)90023-7

Robertsonian translocation studies on the significance of Trisomy 15 in murine T-cell leukemia

Jack Spira
, Francis Wiener
, George Klein

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

G-banding analysis was carried out on T-cell leukemias induced in various Robertsonian mice by 7,12 dimethylbenz (a) anthracene (DMBA), N-methyl-N-nitrosourea (MNU), or Moloney virus. Trisomy 15 was the only regularly seen chromosome aberration whether chromosome No. 15 was involved in a centric fusion or not. Translocated No. 15 chromosomes were not preferentially duplicated. These results show that it is not the translocated state of chromosome No. 15 but the genetic content that is of importance in leukemia development.

Original language	English
Pages (from-to)	45-49
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0165-4608(83)90023-7
State	Published - May 1983
Externally published	Yes

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title = "Robertsonian translocation studies on the significance of Trisomy 15 in murine T-cell leukemia",

abstract = "G-banding analysis was carried out on T-cell leukemias induced in various Robertsonian mice by 7,12 dimethylbenz (a) anthracene (DMBA), N-methyl-N-nitrosourea (MNU), or Moloney virus. Trisomy 15 was the only regularly seen chromosome aberration whether chromosome No. 15 was involved in a centric fusion or not. Translocated No. 15 chromosomes were not preferentially duplicated. These results show that it is not the translocated state of chromosome No. 15 but the genetic content that is of importance in leukemia development.",

author = "Jack Spira and Francis Wiener and George Klein",

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T1 - Robertsonian translocation studies on the significance of Trisomy 15 in murine T-cell leukemia

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AU - Wiener, Francis

AU - Klein, George

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AB - G-banding analysis was carried out on T-cell leukemias induced in various Robertsonian mice by 7,12 dimethylbenz (a) anthracene (DMBA), N-methyl-N-nitrosourea (MNU), or Moloney virus. Trisomy 15 was the only regularly seen chromosome aberration whether chromosome No. 15 was involved in a centric fusion or not. Translocated No. 15 chromosomes were not preferentially duplicated. These results show that it is not the translocated state of chromosome No. 15 but the genetic content that is of importance in leukemia development.

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U2 - 10.1016/0165-4608(83)90023-7

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JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Robertsonian translocation studies on the significance of Trisomy 15 in murine T-cell leukemia

Abstract

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