Roadmap of the Early Events of In Vivo Somatic Cell Reprogramming

Diana Guallar

doi:10.1089/cell.2022.0160

Roadmap of the Early Events of In Vivo Somatic Cell Reprogramming

Diana Guallar

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Single-cell transcriptomics and in situ imaging of murine pancreas upon partial reprogramming in vivo reveal transcriptional dynamics upon Oct4, Sox2, Klf4, and cMyc (OSKM) induction. Interestingly, transcriptomic signatures of partial reprogramming observed in pancreas are shared by several tissues upon OSKM induction as well as during in vitro reprogramming of fibroblasts, pointing to the existence of conserved pathways critical for early reprogramming, regeneration, and rejuvenation.

Original language	English
Pages (from-to)	7-8
Number of pages	2
Journal	Cellular Reprogramming
Volume	25
Issue number	1
DOIs	https://doi.org/10.1089/cell.2022.0160
State	Published - 1 Feb 2023
Externally published	Yes

Keywords

in vivo reprogramming
plasticity
rejuvenation
single cell

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10.1089/cell.2022.0160

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abstract = "Single-cell transcriptomics and in situ imaging of murine pancreas upon partial reprogramming in vivo reveal transcriptional dynamics upon Oct4, Sox2, Klf4, and cMyc (OSKM) induction. Interestingly, transcriptomic signatures of partial reprogramming observed in pancreas are shared by several tissues upon OSKM induction as well as during in vitro reprogramming of fibroblasts, pointing to the existence of conserved pathways critical for early reprogramming, regeneration, and rejuvenation.",

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AB - Single-cell transcriptomics and in situ imaging of murine pancreas upon partial reprogramming in vivo reveal transcriptional dynamics upon Oct4, Sox2, Klf4, and cMyc (OSKM) induction. Interestingly, transcriptomic signatures of partial reprogramming observed in pancreas are shared by several tissues upon OSKM induction as well as during in vitro reprogramming of fibroblasts, pointing to the existence of conserved pathways critical for early reprogramming, regeneration, and rejuvenation.

KW - in vivo reprogramming

KW - plasticity

KW - rejuvenation

KW - single cell

UR - https://www.scopus.com/pages/publications/85148250738

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DO - 10.1089/cell.2022.0160

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Roadmap of the Early Events of In Vivo Somatic Cell Reprogramming

Abstract

Keywords

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