Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review

Kristin Hsieh, Julie R. Bloom, Daniel R. Dickstein, Anuja Shah, Catherine Yu, Anthony D. Nehlsen, Lucas Resende Salgado, Vishal Gupta, Manjeet Chadha, Kunal K. Sindhu

Research output: Contribution to journalReview articlepeer-review


Endometrial cancer is the most common gynecologic cancer in the United States and it contributes to the second most gynecologic cancer-related deaths. With upfront surgery, the specific characteristics of both the patient and tumor allow for risk-tailored treatment algorithms including adjuvant radiotherapy and systemic therapy. In this narrative review, we discuss the current radiation treatment paradigm for endometrial cancer with an emphasis on various radiotherapy modalities, techniques, and dosing regimens. We then elaborate on how to tailor radiotherapy treatment courses in combination with other cancer-directed treatments, including chemotherapy and immunotherapy. In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes.

Original languageEnglish
Article number1346
Issue number7
StatePublished - Apr 2024


  • endometrial cancer
  • personalized treatment
  • radiation oncology
  • radiation-induced toxicities
  • radiotherapy
  • risk-tailoring
  • uterine malignancy


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