Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review

Kristin Hsieh; Julie R. Bloom; Daniel R. Dickstein; Anuja Shah; Catherine Yu; Anthony D. Nehlsen; Lucas Resende Salgado; Vishal Gupta; Manjeet Chadha; Kunal K. Sindhu

doi:10.3390/cancers16071346

Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review

Kristin Hsieh, Julie R. Bloom, Daniel R. Dickstein, Anuja Shah, Catherine Yu, Anthony D. Nehlsen, Lucas Resende Salgado, Vishal Gupta, Manjeet Chadha, Kunal K. Sindhu

Research output: Contribution to journal › Review article › peer-review

Abstract

Endometrial cancer is the most common gynecologic cancer in the United States and it contributes to the second most gynecologic cancer-related deaths. With upfront surgery, the specific characteristics of both the patient and tumor allow for risk-tailored treatment algorithms including adjuvant radiotherapy and systemic therapy. In this narrative review, we discuss the current radiation treatment paradigm for endometrial cancer with an emphasis on various radiotherapy modalities, techniques, and dosing regimens. We then elaborate on how to tailor radiotherapy treatment courses in combination with other cancer-directed treatments, including chemotherapy and immunotherapy. In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes.

Original language	English
Article number	1346
Journal	Cancers
Volume	16
Issue number	7
DOIs	https://doi.org/10.3390/cancers16071346
State	Published - Apr 2024

Keywords

endometrial cancer
personalized treatment
radiation oncology
radiation-induced toxicities
radiotherapy
risk-tailoring
uterine malignancy

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10.3390/cancers16071346

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title = "Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review",

abstract = "Endometrial cancer is the most common gynecologic cancer in the United States and it contributes to the second most gynecologic cancer-related deaths. With upfront surgery, the specific characteristics of both the patient and tumor allow for risk-tailored treatment algorithms including adjuvant radiotherapy and systemic therapy. In this narrative review, we discuss the current radiation treatment paradigm for endometrial cancer with an emphasis on various radiotherapy modalities, techniques, and dosing regimens. We then elaborate on how to tailor radiotherapy treatment courses in combination with other cancer-directed treatments, including chemotherapy and immunotherapy. In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes.",

keywords = "endometrial cancer, personalized treatment, radiation oncology, radiation-induced toxicities, radiotherapy, risk-tailoring, uterine malignancy",

author = "Kristin Hsieh and Bloom, {Julie R.} and Dickstein, {Daniel R.} and Anuja Shah and Catherine Yu and Nehlsen, {Anthony D.} and {Resende Salgado}, Lucas and Vishal Gupta and Manjeet Chadha and Sindhu, {Kunal K.}",

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doi = "10.3390/cancers16071346",

language = "English",

volume = "16",

journal = "Cancers",

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T1 - Risk-Tailoring Radiotherapy for Endometrial Cancer

T2 - A Narrative Review

AU - Hsieh, Kristin

AU - Bloom, Julie R.

AU - Dickstein, Daniel R.

AU - Shah, Anuja

AU - Yu, Catherine

AU - Nehlsen, Anthony D.

AU - Resende Salgado, Lucas

AU - Gupta, Vishal

AU - Chadha, Manjeet

AU - Sindhu, Kunal K.

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N2 - Endometrial cancer is the most common gynecologic cancer in the United States and it contributes to the second most gynecologic cancer-related deaths. With upfront surgery, the specific characteristics of both the patient and tumor allow for risk-tailored treatment algorithms including adjuvant radiotherapy and systemic therapy. In this narrative review, we discuss the current radiation treatment paradigm for endometrial cancer with an emphasis on various radiotherapy modalities, techniques, and dosing regimens. We then elaborate on how to tailor radiotherapy treatment courses in combination with other cancer-directed treatments, including chemotherapy and immunotherapy. In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes.

AB - Endometrial cancer is the most common gynecologic cancer in the United States and it contributes to the second most gynecologic cancer-related deaths. With upfront surgery, the specific characteristics of both the patient and tumor allow for risk-tailored treatment algorithms including adjuvant radiotherapy and systemic therapy. In this narrative review, we discuss the current radiation treatment paradigm for endometrial cancer with an emphasis on various radiotherapy modalities, techniques, and dosing regimens. We then elaborate on how to tailor radiotherapy treatment courses in combination with other cancer-directed treatments, including chemotherapy and immunotherapy. In conclusion, this review summarizes ongoing research that aims to further individualize radiotherapy regimens for individuals in an attempt to improve patient outcomes.

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KW - personalized treatment

KW - radiation oncology

KW - radiation-induced toxicities

KW - radiotherapy

KW - risk-tailoring

KW - uterine malignancy

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Risk-Tailoring Radiotherapy for Endometrial Cancer: A Narrative Review

Abstract

Keywords

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