TY - JOUR
T1 - Risk scores in acute coronary syndrome and percutaneous coronary intervention
T2 - A review
AU - Bawamia, Bilal
AU - Mehran, Roxana
AU - Qiu, Weiliang
AU - Kunadian, Vijay
N1 - Funding Information:
The literature review was conducted on PubMed and Medline using the following search terms: ‘risk score’, ‘acute coronary syndrome’, ‘percutaneous coronary intervention’, ‘mortality’, ‘myocardial infarction’, ‘major adverse cardiac events’. References for included studies were also searched and evaluated. For each risk score, the strengths and limitations of the original derivation study were assessed and evidence of external validation sought. The research was supported by the National Institute for Health Research Newcastle Biomedical Research Centre based at Newcastle upon Tyne Hospitals National Health Service Foundation Trust and Newcastle University. The views expressed are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research or the Department of Health.
PY - 2013/4
Y1 - 2013/4
N2 - Patients with acute coronary syndrome (ACS) need to be risk stratified to deliver the most appropriate therapy. The GRACE and TIMI risk scores have penetrated contemporary guidelines with the former most commonly used in clinical practice. However, ACS prediction models need to be re-evaluated in contemporary practice with evolving diagnostic and treatment options. Moreover, the increased availability of percutaneous coronary intervention (PCI) as a treatment option for ACS combined with an expanding case mix and emphasis on quality control have triggered the creation of PCI specific prognostic models. These allow clinicians and patients to have an understanding of expected outcomes following PCI by predicting outcomes in-hospital to 5 years following intervention. The aim of this review is to evaluate the most recognized and studied ACS/PCI risk models, focusing on their strengths and limitations, and to assess the need for more robust tools to predict outcomes in a period of constantly advancing technologies and changing patient demographics.
AB - Patients with acute coronary syndrome (ACS) need to be risk stratified to deliver the most appropriate therapy. The GRACE and TIMI risk scores have penetrated contemporary guidelines with the former most commonly used in clinical practice. However, ACS prediction models need to be re-evaluated in contemporary practice with evolving diagnostic and treatment options. Moreover, the increased availability of percutaneous coronary intervention (PCI) as a treatment option for ACS combined with an expanding case mix and emphasis on quality control have triggered the creation of PCI specific prognostic models. These allow clinicians and patients to have an understanding of expected outcomes following PCI by predicting outcomes in-hospital to 5 years following intervention. The aim of this review is to evaluate the most recognized and studied ACS/PCI risk models, focusing on their strengths and limitations, and to assess the need for more robust tools to predict outcomes in a period of constantly advancing technologies and changing patient demographics.
UR - https://www.scopus.com/pages/publications/84875434754
U2 - 10.1016/j.ahj.2012.12.020
DO - 10.1016/j.ahj.2012.12.020
M3 - Review article
AN - SCOPUS:84875434754
SN - 0002-8703
VL - 165
SP - 441
EP - 450
JO - American Heart Journal
JF - American Heart Journal
IS - 4
ER -