Objective: Previous work in adults and youths has suggested that juvenile onset bipolar disorder (BPD) is associated with an elevated risk of substance use disorders (SUD). Considering the public health importance of this issue, the authors now report on a controlled study of adolescents with and without BPD to evaluate the risk of SUD. Method: Probands with DSM-IV BPD (n = 57, mean age ± SD = 13.3 ± 2.4 years) and without DSM-IV BPD (n = 46, 13.6 ± 2.2 years) were studied. Structured psychiatric interviews and multiple measures of SUD were collected. Results: Bipolar disorder was associated with a highly significant risk factor for SUD (32% versus 7%, Z = 2.9, p = .004) that was not accounted for by conduct disorder (adjusted odds ratio = 5.4, p = .018). Adolescent-onset BPD (≥13 years) was associated with a higher risk of SUD compared with those with child-onset BPD (χ21 = 9.3, p = .002). Conclusions: These findings strongly indicate that BPD, especially adolescent onset, is a significant risk factor for SUD independently of conduct disorder.
|Number of pages||7|
|Journal||Journal of the American Academy of Child and Adolescent Psychiatry|
|State||Published - Nov 2004|
- Bipolar disorder
- Substance abuse