Risk of readmission for suicide attempt after epilepsy hospitalization

Kevin Y. Xu, Kyle C. Rossi, Anna M. Kim, Nathalie Jetté, Ji Yeoun Yoo, Kenneth Hung, Mandip S. Dhamoon

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: The objective of this study was to examine if epilepsy admissions are associated with a higher readmission risk for suicide attempt, independent of psychiatric comorbidity, compared with index admissions for other medical causes. Methods: The Nationwide Readmissions Database is a nationally representative dataset containing data from roughly 15 million hospital discharges. Analysis of International Classification of Disease Clinical Modification 9 (ICD-9-CM) codes in the year 2013 revealed 58,278 index admissions for epilepsy; this group was compared with admissions for stroke (N = 215,821) and common medical causes (N = 973,078). Ninety-day readmission rates for suicide attempts were calculated. Cox regression tested for associations between admission type and suicide attempt readmissions up to 1 year following index admission. Results: There were 402/100,000 readmissions for suicide attempt within 90 days from index admission in the group with epilepsy; 43/100,000 in the stroke group; and between 37 and 89/100,000 in the medical group. Unadjusted hazard ratios (HR) for suicide readmissions within 1 year in the group with epilepsy compared with the stroke group were 9.61 (95% confidence interval (CI): 7.69–11.90, p < 2.0 × 10− 16) and 5.02 compared with the medical group (95% CI: 4.40–5.73, p < 2.0 × 10 16). The HR for readmission in the group with epilepsy, after adjustment for sociodemographic and psychiatric variables, were elevated at 4.91 compared with the stroke group (95% CI: 3.83–6.27, p < 2.0 × 10− 16), and 2.66 compared with the medical group (95% CI: 2.32–3.05, p < 2.0 × 10− 16). Conclusion: Independent of psychiatric comorbidities, epilepsy admissions may be independently associated with more than a threefold increased risk of hospital readmission for suicide in the year following index admission in comparison with patients recently hospitalized because of stroke or other common medical disorders.

Original languageEnglish
Pages (from-to)124-130
Number of pages7
JournalEpilepsy and Behavior
StatePublished - Jun 2018


  • Epilepsy
  • Hospitalizations
  • Readmissions
  • Seizures
  • Suicide


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