Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma

Uchechukwu C. Megwalu, Davud Sirjani

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Objective: To determine the risk of nodal metastasis, examine risk factors for nodal metastasis, and evaluate the impact of nodal metastasis on survival in patients with major salivary gland adenoid cystic carcinoma. Study Design: Retrospective cohort study from a large population- based cancer database. Methods: Data were extracted from the SEER 18 database (Surveillance, Epidemiology, and End Results) of the National Cancer Institute. The study cohort included 720 patients diagnosed with major salivary gland adenoid cystic carcinoma between 1988 and 2013. Results: The overall rate of lymph node metastasis was 17%. T3 disease (odds ratio, 4.74) and T4 disease (odds ratio, 9.24) were associated with increased risk of nodal metastasis. Age, sex, and site were not associated with nodal metastasis. Nodal metastasis was associated with worse overall survival (hazard ratio, 2.56) and disease-specific survival (hazard ratio, 3.27), after adjusting for T stage, presence of distant metastasis, site, surgical resection, radiotherapy, neck dissection, age, sex, race, marital status, and year of diagnosis. Conclusion: Major salivary gland adenoid cystic carcinoma carries significant risk of nodal metastasis. Advanced T stage is associated with increased risk of nodal metastasis. Nodal metastasis is associated with worse survival.

Original languageEnglish
Pages (from-to)660-664
Number of pages5
JournalOtolaryngology - Head and Neck Surgery
Volume156
Issue number4
DOIs
StatePublished - 1 Apr 2017
Externally publishedYes

Keywords

  • SEER program
  • adenoid cystic carcinoma
  • head and neck cancer
  • lymph node
  • neoplasm metastasis
  • salivary gland cancer

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