Risk Factors of Portal Vein Thrombosis in Crohn's Disease Patients

Galen G. Leung, Muthu V. Sivasankaran, Jacqueline J. Choi, Celia M. Divino

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Introduction: Patients with inflammatory bowel disease, such as Crohn's disease (CD), suffer from a threefold increase in the risk of venous thromboembolism. Small bowel, segmental bowel, or ileocolonic resection to treat Crohn's disease can lead to rare complications of portal vein thrombosis (PVT), which can lead to further poor health outcomes, such as small bowel ischemia. The study attempts to find different risk factors that may be associated with postoperative complications of PVT in Crohn's disease patients. Methods: In a 1 to 3 case-control study following Institutional Review Board approval, 13 Crohn's disease patients with documented radiological postoperative diagnosis of PVT from 2004 to 2011 and 39 CD patients who did not have postoperative PVT were matched by retrospective chart review for patient demographics, preoperative course and workup, anticoagulant use, and operative procedure. Univariate analysis was performed to draw correlations on risk factors for the development of PVT. Results: In the 13 CD patients with PVT, concurrent cancer, liver disease, and dyslipidemia were present in 23. 1%, 23. 1%, and 15. 4% of the population, respectively. Compared to the 39 CD only patients, concurrent cancer, liver disease, and dyslipidemia were present in only 2. 6%, 2. 6%, and 0% of the population, respectively. Of the CD patients with PVT, 61. 5% were on preoperative steroids compared to 28. 9% of the CD only patients. PVT development in CD patients is correlated with concurrent cancer (p = 0. 016), liver disease (p = 0. 016), dyslipidemia (p = 0. 012), and preoperative steroid usage (p = 0. 036). Conclusions: Concurrent cancer, liver disease, dyslipidemia, and preoperative steroid usage were risk factors associated with the development of PVT in Crohn's patients. Since there is limited literature on PVT in CD, more data needs to be collected, and additional studies should be done to further assess the prevention, diagnosis, and management of the disease.

Original languageEnglish
Pages (from-to)1199-1203
Number of pages5
JournalJournal of Gastrointestinal Surgery
Issue number6
StatePublished - Jun 2012


  • Crohn's disease
  • Portal Vein thrombosis
  • Post-operative complications in Crohn's disease
  • Risk Factors
  • Venous thromboembolism


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