TY - JOUR
T1 - Risk factors for urinary tract infection following incontinence surgery
AU - Nygaard, Ingrid
AU - Brubaker, Linda
AU - Chai, Toby C.
AU - Markland, Alayne D.
AU - Menefee, Shawn A.
AU - Sirls, Larry
AU - Sutkin, Gary
AU - Zimmern, Phillipe
AU - Arisco, Amy
AU - Huang, Liyuan
AU - Tennstedt, Sharon
AU - Stoddard, Anne
N1 - Funding Information:
Acknowledgments This study was supported by NIH grants U01 DK58231, U01 DK60379, U01 DK60380, U01 DK60401, U01 DK60397, U01 DK 58225, U01 DK60395, U01 DK58234, U01 DK60393, U01 DK58229.
Funding Information:
Conflicts of interest The authors report no financial disclosures with the following exceptions: Linda Brubaker received grant support and honorarium from Pfizer; Toby Chai received grant support from Allergan and honorarium from Pfizer; Anne Stoddard has stocks in Bristol-Meyers Squibb, Johnson and Johnson, Elan Corp., Proctor and Gamble, and Stryker.
PY - 2011/10
Y1 - 2011/10
N2 - Introduction and hypothesis The purpose of this study is to describe risk factors for post-operative urinary tract infection (UTI) the first year after stress urinary incontinence surgery. Methods Multivariable logistic regression analyses were performed on data from 1,252 women randomized in two surgical trials, Stress Incontinence Surgical Treatment Efficacy trial (SISTEr) and Trial OfMid-Urethral Slings (TOMUS). Results Baseline recurrent UTI (rUTI; =3 in 12 months) increased the risk of UTI in the first 6 weeks in both study populations, as did sling procedure and self-catheterization in SISTEr, and bladder perforation in TOMUS. Baseline rUTI, UTI in the first 6 weeks, and PVR>100 cc at 12 months were independent risk factors for UTI between 6 weeks and 12 months in the SISTEr population. Few (2.3-2.4%) had post-operative rUTI, precluding multivariable analysis. In women with pre-operative rUTI, successful surgery (negative cough stress test) at 1 year did not appear to decrease the risk of persistent rUTI. Conclusions Pre-operative rUTI is the strongest risk factor for post-operative UTI.
AB - Introduction and hypothesis The purpose of this study is to describe risk factors for post-operative urinary tract infection (UTI) the first year after stress urinary incontinence surgery. Methods Multivariable logistic regression analyses were performed on data from 1,252 women randomized in two surgical trials, Stress Incontinence Surgical Treatment Efficacy trial (SISTEr) and Trial OfMid-Urethral Slings (TOMUS). Results Baseline recurrent UTI (rUTI; =3 in 12 months) increased the risk of UTI in the first 6 weeks in both study populations, as did sling procedure and self-catheterization in SISTEr, and bladder perforation in TOMUS. Baseline rUTI, UTI in the first 6 weeks, and PVR>100 cc at 12 months were independent risk factors for UTI between 6 weeks and 12 months in the SISTEr population. Few (2.3-2.4%) had post-operative rUTI, precluding multivariable analysis. In women with pre-operative rUTI, successful surgery (negative cough stress test) at 1 year did not appear to decrease the risk of persistent rUTI. Conclusions Pre-operative rUTI is the strongest risk factor for post-operative UTI.
KW - Recurrent urinary tract infection
KW - Risk factors
KW - Stress urinary incontinence surgery
KW - Urinary tract infection
UR - http://www.scopus.com/inward/record.url?scp=84855251065&partnerID=8YFLogxK
U2 - 10.1007/s00192-011-1429-9
DO - 10.1007/s00192-011-1429-9
M3 - Article
C2 - 21560012
AN - SCOPUS:84855251065
SN - 0937-3462
VL - 22
SP - 1255
EP - 1265
JO - International Urogynecology Journal
JF - International Urogynecology Journal
IS - 10
ER -