Rheumatoid arthritis association at 6q23

Wellcome Trust Case Control Consortium, YEAR Consortium, The Biologics in RA Genetics and Genomics BRAGGS

Research output: Contribution to journalArticlepeer-review

331 Scopus citations

Abstract

The Wellcome Trust Case Control Consortium (WTCCC) identified nine single SNPs putatively associated with rheumatoid arthritis at P = 1 × 10 -5 - 5 × 10-7 in a genome-wide association screen. One, rs6920220, was unequivocally replicated (trend P = 1.1 × 10 -8) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-α-induced protein 3 (TNFAIP3).

Original languageEnglish
Pages (from-to)1431-1433
Number of pages3
JournalNature Genetics
Volume39
Issue number12
DOIs
StatePublished - 1 Dec 2007
Externally publishedYes

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