Rhabdomyolysis following clarithromycin monotherapy

Zachary Z. Brener; Ilya Bilik; Boris Khorets; James F. Winchester; Michael Bergman

doi:10.1097/MAJ.0b013e31819e221f

Rhabdomyolysis following clarithromycin monotherapy

Zachary Z. Brener, Ilya Bilik, Boris Khorets, James F. Winchester, Michael Bergman

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis. We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications. Inhibition of cytochrome P450 could be one of the potential causative mechanisms of myopathy in our case. Clinicians should be aware of this potential adverse effect of a widely used drug.

Original language	English
Pages (from-to)	78
Number of pages	1
Journal	American Journal of the Medical Sciences
Volume	338
Issue number	1
DOIs	https://doi.org/10.1097/MAJ.0b013e31819e221f
State	Published - Jul 2009
Externally published	Yes

Keywords

Clarithromycin
Macrolides
Myopathy
Renal failure
Rhabdomyolysis

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10.1097/MAJ.0b013e31819e221f

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title = "Rhabdomyolysis following clarithromycin monotherapy",

abstract = "Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis. We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications. Inhibition of cytochrome P450 could be one of the potential causative mechanisms of myopathy in our case. Clinicians should be aware of this potential adverse effect of a widely used drug.",

keywords = "Clarithromycin, Macrolides, Myopathy, Renal failure, Rhabdomyolysis",

author = "Brener, \{Zachary Z.\} and Ilya Bilik and Boris Khorets and Winchester, \{James F.\} and Michael Bergman",

year = "2009",

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T1 - Rhabdomyolysis following clarithromycin monotherapy

AU - Brener, Zachary Z.

AU - Bilik, Ilya

AU - Khorets, Boris

AU - Winchester, James F.

AU - Bergman, Michael

PY - 2009/7

Y1 - 2009/7

N2 - Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis. We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications. Inhibition of cytochrome P450 could be one of the potential causative mechanisms of myopathy in our case. Clinicians should be aware of this potential adverse effect of a widely used drug.

AB - Macrolide antibiotics inhibit the metabolism of hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) that may result in myopathy and rhabdomyolysis. We report the first case of rhabdomyolysis related to the administration of clarithromycin without concurrent use of other medications. Inhibition of cytochrome P450 could be one of the potential causative mechanisms of myopathy in our case. Clinicians should be aware of this potential adverse effect of a widely used drug.

KW - Clarithromycin

KW - Macrolides

KW - Myopathy

KW - Renal failure

KW - Rhabdomyolysis

UR - https://www.scopus.com/pages/publications/68849132283

U2 - 10.1097/MAJ.0b013e31819e221f

DO - 10.1097/MAJ.0b013e31819e221f

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VL - 338

SP - 78

JO - American Journal of the Medical Sciences

JF - American Journal of the Medical Sciences

IS - 1

ER -

Rhabdomyolysis following clarithromycin monotherapy

Abstract

Keywords

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