TY - JOUR
T1 - Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages
AU - Emile, Jean François
AU - Abla, Oussama
AU - Fraitag, Sylvie
AU - Horne, Annacarin
AU - Haroche, Julien
AU - Donadieu, Jean
AU - Requena-Caballero, Luis
AU - Jordan, Michael B.
AU - Abdel-Wahab, Omar
AU - Allen, Carl E.
AU - Charlotte, Frédéric
AU - Diamond, Eli L.
AU - Egeler, R. Maarten
AU - Fischer, Alain
AU - Herrera, Juana Gil
AU - Henter, Jan Inge
AU - Janku, Filip
AU - Merad, Miriam
AU - Picarsic, Jennifer
AU - Rodriguez-Galindo, Carlos
AU - Rollins, Barret J.
AU - Tazi, Abdellatif
AU - Vassallo, Robert
AU - Weiss, Lawrence M.
AU - Histiocyte Society, Society
N1 - Publisher Copyright:
© 2016 by The American Society of Hematology.
PY - 2016/6/2
Y1 - 2016/6/2
N2 - The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.
AB - The histiocytoses are rare disorders characterized by the accumulation of macrophage, dendritic cell, or monocyte-derived cells in various tissues and organs of children and adults. More than 100 different subtypes have been described, with a wide range of clinical manifestations, presentations, and histologies. Since the first classification in 1987, a number of new findings regarding the cellular origins, molecular pathology, and clinical features of histiocytic disorders have been identified. We propose herein a revision of the classification of histiocytoses based on histology, phenotype, molecular alterations, and clinical and imaging characteristics. This revised classification system consists of 5 groups of diseases: (1) Langerhans-related, (2) cutaneous and mucocutaneous, and (3) malignant histiocytoses as well as (4) Rosai-Dorfman disease and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. Herein, we provide guidelines and recommendations for diagnoses of these disorders.
UR - https://www.scopus.com/pages/publications/84971328245
U2 - 10.1182/blood-2016-01-690636
DO - 10.1182/blood-2016-01-690636
M3 - Review article
C2 - 26966089
AN - SCOPUS:84971328245
SN - 0006-4971
VL - 127
SP - 2672
EP - 2681
JO - Blood
JF - Blood
IS - 22
ER -