Review old bone, new tricks

Livnat Barsky, Ifat Cohen-Erez, Igor Bado, Xiang H.F. Zhang, Razi Vago

Research output: Contribution to journalReview articlepeer-review

Abstract

Despite the significant progress made over the past decade with combination of molecular profiling data and the development of new clinical strategies, our understanding of metastasis remains elusive. Bone metastasis is a complex process and a major cause of mortality in breast and prostate cancer patients, for which there is no effective treatment to-date. The current review summarizes the routes taken by the metastatic cells and the interactions between them and the bone microenvironment. We emphasize the role of the specified niches and cues that promote cellular adhesion, colonization, prolonged dormancy, and reactivation. Understanding these mechanisms will provide better insights for future studies and treatment strategies for bone metastatic conditions.

Original languageEnglish
Pages (from-to)727-742
Number of pages16
JournalClinical and Experimental Metastasis
Volume39
Issue number5
DOIs
StatePublished - Oct 2022
Externally publishedYes

Keywords

  • Bone metastasis
  • Breast cancer
  • Dormancy
  • Endosteal niche
  • Perivascular niche
  • Reactivation

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