Review: Ischemia reperfusion injury—a translational perspective in organ transplantation

André Renaldo Fernández, Rodrigo Sánchez-Tarjuelo, Paolo Cravedi, Jordi Ochando, Marcos López-Hoyos

Research output: Contribution to journalReview articlepeer-review

56 Scopus citations

Abstract

Thanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI.

Original languageEnglish
Article number8549
Pages (from-to)1-21
Number of pages21
JournalInternational Journal of Molecular Sciences
Volume21
Issue number22
DOIs
StatePublished - 2 Nov 2020

Keywords

  • Cell death
  • Cell metabolism
  • Hypoxia
  • Innate immunity
  • Ischemia reperfusion injury
  • RNA interference

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