Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With                          89                         Zr-Labeled Reporter Nanoparticles

Govindarajan Srimathveeravalli; Dalya Abdel-Atti; Carlos Pérez-Medina; Haruyuki Takaki; Stephen B. Solomon; Willem J.M. Mulder; Thomas Reiner

doi:10.1177/1536012117749726

Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With ⁸⁹ Zr-Labeled Reporter Nanoparticles

Govindarajan Srimathveeravalli, Dalya Abdel-Atti, Carlos Pérez-Medina, Haruyuki Takaki, Stephen B. Solomon, Willem J.M. Mulder, Thomas Reiner

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( ⁸⁹ Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered ⁸⁹ Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of ⁸⁹ Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of ⁸⁹ Zr-NRep in tumors. ⁸⁹ Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated ⁸⁹ Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with ⁸⁹ Zr-NRep.

Original language	English
Journal	Molecular Imaging
Volume	17
DOIs	https://doi.org/10.1177/1536012117749726
State	Published - 20 Feb 2018

Keywords

animal PET
drug delivery
nanoparticle

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10.1177/1536012117749726

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Srimathveeravalli, G., Abdel-Atti, D., Pérez-Medina, C., Takaki, H., Solomon, S. B., Mulder, W. J. M., & Reiner, T. (2018). Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With ⁸⁹ Zr-Labeled Reporter Nanoparticles Molecular Imaging, 17. https://doi.org/10.1177/1536012117749726

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title = " Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With 89 Zr-Labeled Reporter Nanoparticles ",

abstract = " Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered 89 Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of 89 Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of 89 Zr-NRep in tumors. 89 Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated 89 Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89 Zr-NRep.",

keywords = "animal PET, drug delivery, nanoparticle",

author = "Govindarajan Srimathveeravalli and Dalya Abdel-Atti and Carlos P{\'e}rez-Medina and Haruyuki Takaki and Solomon, \{Stephen B.\} and Mulder, \{Willem J.M.\} and Thomas Reiner",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018.",

year = "2018",

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doi = "10.1177/1536012117749726",

language = "English",

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Srimathveeravalli, G, Abdel-Atti, D, Pérez-Medina, C, Takaki, H, Solomon, SB, Mulder, WJM & Reiner, T 2018, ' Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With ⁸⁹ Zr-Labeled Reporter Nanoparticles ', Molecular Imaging, vol. 17. https://doi.org/10.1177/1536012117749726

Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With ⁸⁹ Zr-Labeled Reporter Nanoparticles . / Srimathveeravalli, Govindarajan; Abdel-Atti, Dalya; Pérez-Medina, Carlos et al.
In: Molecular Imaging, Vol. 17, 20.02.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With 89 Zr-Labeled Reporter Nanoparticles

AU - Srimathveeravalli, Govindarajan

AU - Abdel-Atti, Dalya

AU - Pérez-Medina, Carlos

AU - Takaki, Haruyuki

AU - Solomon, Stephen B.

AU - Mulder, Willem J.M.

AU - Reiner, Thomas

PY - 2018/2/20

Y1 - 2018/2/20

N2 - Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered 89 Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of 89 Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of 89 Zr-NRep in tumors. 89 Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated 89 Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89 Zr-NRep.

AB - Reversible electroporation (RE) can facilitate nanoparticle delivery to tumors through direct transfection and from changes in vascular permeability. We investigated a radiolabeled liposomal nanoparticle ( 89 Zr-NRep) for monitoring RE-mediated liposomal doxorubicin (DOX) delivery in mouse tumors. Intravenously delivered 89 Zr-NRep allowed positron emission tomography imaging of electroporation-mediated nanoparticle uptake. The relative order of 89 Zr-NRep injection and electroporation did not result in significantly different overall tumor uptake, suggesting direct transfection and vascular permeability can independently mediate deposition of 89 Zr-NRep in tumors. 89 Zr-NRep and DOX uptake correlated well in both electroporated and control tumors at all experimental time points. Electroporation accelerated 89 Zr-NRep and DOX deposition into tumors and increased DOX dosing. Reversible electroporation–related vascular effects seem to play an important role in nanoparticle delivery to tumors and drug uptake can be quantified with 89 Zr-NRep.

KW - animal PET

KW - drug delivery

KW - nanoparticle

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DO - 10.1177/1536012117749726

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JO - Molecular Imaging

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ER -

Srimathveeravalli G, Abdel-Atti D, Pérez-Medina C, Takaki H, Solomon SB, Mulder WJM et al. Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With ⁸⁹ Zr-Labeled Reporter Nanoparticles Molecular Imaging. 2018 Feb 20;17. doi: 10.1177/1536012117749726

Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With 89 Zr-Labeled Reporter Nanoparticles

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Keywords

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Reversible Electroporation–Mediated Liposomal Doxorubicin Delivery to Tumors Can Be Monitored With ⁸⁹ Zr-Labeled Reporter Nanoparticles