Reversible Acute Renal Failure Induced by Indomethacin

Siang Y. Tan; Ronald Shapiro; Mary Ann Kish

doi:10.1001/jama.1979.03290510040025

Reversible Acute Renal Failure Induced by Indomethacin

Siang Y. Tan, Ronald Shapiro, Mary Ann Kish

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Abstract

Acute renal failure occurred during indomethacin therapy in a patient with chronic pyelonephritis. Urinary prostaglandin E2 levels were diminished but returned to normal after discontinuation of drug therapy and recovery of renal function. Prostaglandins may be critical for the integrity of renal function, and the use of prostaglandin inhibitors such as indomethacin and other nonsteroidal anti-inflammatory drugs may be deleterious in patients with underlying renal disease.

Original language	English
Pages (from-to)	2732-2733
Number of pages	2
Journal	JAMA - Journal of the American Medical Association
Volume	241
Issue number	25
DOIs	https://doi.org/10.1001/jama.1979.03290510040025
State	Published - 22 Jun 1979
Externally published	Yes

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10.1001/jama.1979.03290510040025

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title = "Reversible Acute Renal Failure Induced by Indomethacin",

abstract = "Acute renal failure occurred during indomethacin therapy in a patient with chronic pyelonephritis. Urinary prostaglandin E2 levels were diminished but returned to normal after discontinuation of drug therapy and recovery of renal function. Prostaglandins may be critical for the integrity of renal function, and the use of prostaglandin inhibitors such as indomethacin and other nonsteroidal anti-inflammatory drugs may be deleterious in patients with underlying renal disease.",

author = "Tan, {Siang Y.} and Ronald Shapiro and Kish, {Mary Ann}",

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AU - Shapiro, Ronald

AU - Kish, Mary Ann

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AB - Acute renal failure occurred during indomethacin therapy in a patient with chronic pyelonephritis. Urinary prostaglandin E2 levels were diminished but returned to normal after discontinuation of drug therapy and recovery of renal function. Prostaglandins may be critical for the integrity of renal function, and the use of prostaglandin inhibitors such as indomethacin and other nonsteroidal anti-inflammatory drugs may be deleterious in patients with underlying renal disease.

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ER -

Reversible Acute Renal Failure Induced by Indomethacin

Abstract

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