Reversible Acute Renal Failure Induced by Indomethacin

Siang Y. Tan, Ronald Shapiro, Mary Ann Kish

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Acute renal failure occurred during indomethacin therapy in a patient with chronic pyelonephritis. Urinary prostaglandin E2 levels were diminished but returned to normal after discontinuation of drug therapy and recovery of renal function. Prostaglandins may be critical for the integrity of renal function, and the use of prostaglandin inhibitors such as indomethacin and other nonsteroidal anti-inflammatory drugs may be deleterious in patients with underlying renal disease.

Original languageEnglish
Pages (from-to)2732-2733
Number of pages2
JournalJAMA - Journal of the American Medical Association
Issue number25
StatePublished - 22 Jun 1979
Externally publishedYes


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