Reversibility of the differentiated state in somatic cells

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Abstract

Analysis of de novo gene activation in multinucleated heterokaryons has shown that the differentiated state, although stable, is not irreversible, and can be reprogrammed in the presence of appropriate combinations of trans-acting regulatory molecules. These properties have been exploited to design strategies for identifying novel regulators of cellular differentiation.

Original languageEnglish
Pages (from-to)1050-1056
Number of pages7
JournalCurrent Opinion in Cell Biology
Volume5
Issue number6
DOIs
StatePublished - Dec 1993
Externally publishedYes

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