@article{d7512f24eb394fcf9bed0e87dca8ef19,
title = "Reverse cholesterol transport and hepatic osteodystrophy",
abstract = "In this issue of Cell Metabolism, Lu et al. show that chronic liver disease increases the expression and activity of PP2Ac, a phosphatase that downregulates the excretion of lecithin-cholesterol aceyltransferase (LCAT). LCAT, a liver-derived enzyme, protects bone and prevents bone loss, and its lowered levels in progressive liver injury cause hepatic osteodystrophy (HOD) and worsen liver fibrosis. These discoveries open the possibility that recombinant LCAT may be a treatment for both HOD and liver fibrosis.",
author = "Mone Zaidi and Tony Yuen and Jameel Iqbal",
note = "Funding Information: The authors gratefully acknowledge the support of the National Institutes of Health ( R01 AG071870 , R01 AG074092 , and U01 AG073148 to T.Y. and M.Z.; U19 AG060917 to M.Z.; and R01 DK113627 to M.Z. and J.I.). Funding Information: The authors gratefully acknowledge the support of the National Institutes of Health (R01 AG071870, R01 AG074092, and U01 AG073148 to T.Y. and M.Z.; U19 AG060917 to M.Z.; and R01 DK113627 to M.Z. and J.I.). M.Z. is an inventor on issued patents on inhibiting FSH for the prevention and treatment of osteoporosis and obesity (U.S. Patent 8,435,948 and 11,034,761). M.Z. is also an inventor on a pending patent application on composition and use of humanized monoclonal anti-FSH antibodies and is co-inventor of a pending patent on the use of FSH as a target for preventing Alzheimer's disease. These patents are owned by Icahn School of Medicine at Mount Sinai (ISMMS), and M.Z. would be recipient of royalties, per institutional policy. M.Z. also consults for several financial platforms, including Gerson Lehman Group and Guidepoint, on drugs for osteoporosis and genetic bone diseases. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",
year = "2022",
month = mar,
day = "1",
doi = "10.1016/j.cmet.2022.02.007",
language = "English",
volume = "34",
pages = "347--349",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "3",
}