TY - JOUR
T1 - Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer's Diseases
AU - Masmudi-Martín, Mariam
AU - Navarro-Lobato, Irene
AU - López-Aranda, Manuel F.
AU - Browning, Philip G.F.
AU - Simón, Ana María
AU - López-Téllez, Juan F.
AU - Jiménez-Recuerda, Inmaculada
AU - Martín-Montañez, Elisa
AU - Pérez-Mediavilla, Alberto
AU - Frechilla, Diana
AU - Baxter, Mark G.
AU - Khan, Zafar U.
N1 - Funding Information:
We thank Maria E. Quiros-Ortega and Carlos Vivar Rios for technical support. This research was supported by grants from the Ministerio de Economía y Competitividad ( BFU2013-43458-R ) and Junta de Andalucia (P12- CTS -1694 and PI-0542-2013 ) to Z.U.K.
Funding Information:
We thank Maria E. Quiros-Ortega and Carlos Vivar Rios for technical support. This research was supported by grants from the Ministerio de Econom?a y Competitividad (BFU2013-43458-R) and Junta de Andalucia (P12-CTS-1694 and PI-0542-2013) to Z.U.K. Z.U.K. developed the overall research concept and the project; M.M. I.N, M.F.L. M.G.B. P.G-F.B. and Z.U.K. designed the experiments; M.M. I.N. M.F.L. P.G.F.B. and A. S. performed the experiments; J.F.L. I.J. E.M. A.P. and D.F. assisted with the experiments; and M.M. I.N. M.F.L. P.G.F.B. and Z.U.K. wrote the manuscript. The authors declare no competing interests.
Publisher Copyright:
© 2020 IBRO
PY - 2020/11/10
Y1 - 2020/11/10
N2 - The integrity of the perirhinal cortex (PRh) is essential for object recognition memory (ORM) function, and damage to this brain area in animals and humans induces irreversible ORM deficits. Here, we show that activation of area V2, a brain area interconnected with brain circuits of ventral stream and medial temporal lobe that sustain ORM, by expression of regulator of G-protein signaling 14 of 414 amino acids (RGS14414) restored ORM in memory-deficient PRh-lesioned rats and nonhuman primates. Furthermore, this treatment was sufficient for full recovery of ORM in rodent models of aging and Alzheimer's disease, conditions thought to affect multiple brain areas. Thus, RGS14414-mediated activation of area V2 has therapeutic relevance in the recovery of recognition memory, a type of memory that is primarily affected in patients or individuals with symptoms of memory dysfunction. These findings suggest that area V2 modulates the processing of memory-related information through activation of interconnected brain circuits formed by the participation of distinct brain areas.
AB - The integrity of the perirhinal cortex (PRh) is essential for object recognition memory (ORM) function, and damage to this brain area in animals and humans induces irreversible ORM deficits. Here, we show that activation of area V2, a brain area interconnected with brain circuits of ventral stream and medial temporal lobe that sustain ORM, by expression of regulator of G-protein signaling 14 of 414 amino acids (RGS14414) restored ORM in memory-deficient PRh-lesioned rats and nonhuman primates. Furthermore, this treatment was sufficient for full recovery of ORM in rodent models of aging and Alzheimer's disease, conditions thought to affect multiple brain areas. Thus, RGS14414-mediated activation of area V2 has therapeutic relevance in the recovery of recognition memory, a type of memory that is primarily affected in patients or individuals with symptoms of memory dysfunction. These findings suggest that area V2 modulates the processing of memory-related information through activation of interconnected brain circuits formed by the participation of distinct brain areas.
KW - brain memory circuit activation
KW - lesions in perirhinal cortex
KW - memory deficits
KW - recovery of memory dysfunctions
KW - regulator of G protein signaling
UR - http://www.scopus.com/inward/record.url?scp=85091613368&partnerID=8YFLogxK
U2 - 10.1016/j.neuroscience.2020.08.039
DO - 10.1016/j.neuroscience.2020.08.039
M3 - Article
C2 - 32905841
AN - SCOPUS:85091613368
SN - 0306-4522
VL - 448
SP - 287
EP - 298
JO - Neuroscience
JF - Neuroscience
ER -