Abstract

Natural killer (NK) cells are innate immune cells that become progressively exhausted in advanced stage cancer, crippling their ability to execute antitumor functions. We previously characterized the nature of NK cell exhaustion in metastatic melanoma patients, reporting a correlation with high expression of TIM-3. Blockade of this immune checkpoint molecule reversed the exhausted phenotype and improved NK cell function.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalOncoImmunology
Volume3
Issue number12
DOIs
StatePublished - 2 Dec 2014

Keywords

  • Tim-3
  • exhaustion
  • immune checkpoint
  • melanoma
  • natural killer cells

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