TY - GEN
T1 - Revealing Continuous Brain Dynamical Organization with Multimodal Graph Transformer
AU - Zhao, Chongyue
AU - Zhan, Liang
AU - Thompson, Paul M.
AU - Huang, Heng
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - Brain large-scale dynamics is constrained by the heterogeneity of intrinsic anatomical substrate. Little is known how the spatio-temporal dynamics adapt for the heterogeneous structural connectivity (SC). Modern neuroimaging modalities make it possible to study the intrinsic brain activity at the scale of seconds to minutes. Diffusion magnetic resonance imaging (dMRI) and functional MRI reveals the large-scale SC across different brain regions. Electrophysiological methods (i.e. MEG/EEG) provide direct measures of neural activity and exhibits complex neurobiological temporal dynamics which could not be solved by fMRI. However, most of existing multimodal analytical methods collapse the brain measurements either in space or time domain and fail to capture the spatio-temporal circuit dynamics. In this paper, we propose a novel spatio-temporal graph Transformer model to integrate the structural and functional connectivity in both spatial and temporal domain. The proposed method learns the heterogeneous node and graph representation via contrastive learning and multi-head attention based graph Transformer using multimodal brain data (i.e. fMRI, MRI, MEG and behavior performance). The proposed contrastive graph Transformer representation model incorporates the heterogeneity map constrained by T1-to-T2-weighted (T1w/T2w) to improve the model fit to structure-function interactions. The experimental results with multimodal resting state brain measurements demonstrate the proposed method could highlight the local properties of large-scale brain spatio-temporal dynamics and capture the dependence strength between functional connectivity and behaviors. In summary, the proposed method enables the complex brain dynamics explanation for different modal variants.
AB - Brain large-scale dynamics is constrained by the heterogeneity of intrinsic anatomical substrate. Little is known how the spatio-temporal dynamics adapt for the heterogeneous structural connectivity (SC). Modern neuroimaging modalities make it possible to study the intrinsic brain activity at the scale of seconds to minutes. Diffusion magnetic resonance imaging (dMRI) and functional MRI reveals the large-scale SC across different brain regions. Electrophysiological methods (i.e. MEG/EEG) provide direct measures of neural activity and exhibits complex neurobiological temporal dynamics which could not be solved by fMRI. However, most of existing multimodal analytical methods collapse the brain measurements either in space or time domain and fail to capture the spatio-temporal circuit dynamics. In this paper, we propose a novel spatio-temporal graph Transformer model to integrate the structural and functional connectivity in both spatial and temporal domain. The proposed method learns the heterogeneous node and graph representation via contrastive learning and multi-head attention based graph Transformer using multimodal brain data (i.e. fMRI, MRI, MEG and behavior performance). The proposed contrastive graph Transformer representation model incorporates the heterogeneity map constrained by T1-to-T2-weighted (T1w/T2w) to improve the model fit to structure-function interactions. The experimental results with multimodal resting state brain measurements demonstrate the proposed method could highlight the local properties of large-scale brain spatio-temporal dynamics and capture the dependence strength between functional connectivity and behaviors. In summary, the proposed method enables the complex brain dynamics explanation for different modal variants.
KW - Graph contrastive representation
KW - Multimodal graph transformer
KW - Neural graph differential equations
UR - http://www.scopus.com/inward/record.url?scp=85138777654&partnerID=8YFLogxK
U2 - 10.1007/978-3-031-16431-6_33
DO - 10.1007/978-3-031-16431-6_33
M3 - Conference contribution
AN - SCOPUS:85138777654
SN - 9783031164309
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 346
EP - 355
BT - Medical Image Computing and Computer Assisted Intervention – MICCAI 2022 - 25th International Conference, Proceedings
A2 - Wang, Linwei
A2 - Dou, Qi
A2 - Fletcher, P. Thomas
A2 - Speidel, Stefanie
A2 - Li, Shuo
PB - Springer Science and Business Media Deutschland GmbH
T2 - 25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022
Y2 - 18 September 2022 through 22 September 2022
ER -