Retinol binding protein 4 is associated with adiposity-related co-morbidity risk factors in children

Rushika Conroy, Yomery Espinal, Ilene Fennoy, Siham Accacha, Claudia Boucher-Berry, Dennis E. Carey, Sharron Close, Deborah DeSantis, Rishi Gupta, Abeer A. Hassoun, Loretta Iazzetti, Fabean J. Jacques, Amy M. Jean, Lesly Michel, Katherine Pavlovich, Robert Rapaport, Warren Rosenfeld, Elisabeth Shamoon, Steven Shelov, Phyllis W. SpeiserSvetlana Ten, Michael Rosenbaum

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective: In adults, elevated levels of retinol binding protein 4 (RBP4) have been associated with biochemical markers of adiposity-related co-morbidities including insulin resistance, dyslipidemia, hypertension, and abdominal obesity. This study examined the relationship between RBP4 and risk factors for co-morbidities of adiposity in a population of ethnically diverse children in early-to mid-adolescence in the public school system of New York City. Materials/methods: We analyzed anthropometric (body mass index, % body fat, waist circumference), metabolic (lipids, glucose), and inflammatory (TNF-α, interleukin-6, C-reactive protein, adiponectin) markers for adiposity-related co-morbidities and serum alanine aminotransferase (ALT) in 106 school children (65 males, 41 females) 11-15 years of age (mean±SD=13. 0±0.1 years) who were enrolled in the Reduce Obesity and Diabetes (ROAD) project. Insulin sensitivity was assessed by quantitative insulin sensitivity check index. Insulin secretory capacity was measured as acute insulin response and glucose disposal index. Results: Serum RBP4 was significantly correlated directly with ALT, triglycerides, and triglyceride z-score, and inversely correlated with adiponectin. Correlations with ALT and adiponectin remained significant when corrected for % body fat, age, and gender. There were significant ethnic differences in the relationship of RBP4 to ALT, glucose disposal index and adiponectin. Conclusions: In early-to mid-adolescents, circulating concentrations of RBP4 are correlated with multiple risk factors for adiposity-related co-morbidities. The observation that many associations persisted when corrected for % body fat, suggests that RBP4 can be viewed as an independent marker of adiposity-related co-morbidity risk in children.

Original languageEnglish
Pages (from-to)913-919
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number11-12
StatePublished - 1 Dec 2011


  • inflammation
  • insulin resistance
  • lipids
  • obesity


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