Retinal oximetry in glaucoma: investigations and findings reviewed

Aumer Shughoury, Sunu Mathew, Julia Arciero, Patrick Wurster, Susuana Adjei, Thomas Ciulla, Brent Siesky, Alon Harris

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Abnormalities of the retinal blood supply have been widely implicated in primary open-angle glaucoma (POAG). Impaired blood supply to the retina and optic nerve head (ONH) may be a primary pathophysiologic mechanism contributing to POAG (‘vascular hypothesis’). However, the decreased metabolic activity of atrophic tissue is itself known to induce both vascular changes and decreased blood flow due to reduced oxygen demand. Therefore, primary nonvascular factors could potentially induce glaucomatous atrophy, with subsequent secondary vascular pathology (‘mechanical hypothesis’). Retinal oximetry holds great promise in the investigation of glaucoma pathogenesis, as it can provide useful data on retinal metabolic oxygen demand, especially when combined with measurements of retinal blood flow. This review surveys the research on retinal metabolism in POAG using spectroscopic retinal oximetry. The use of mathematical models in combination with oximetric data to investigate the role of retinal metabolism and oxygen supply in POAG is also discussed.

Original languageEnglish
Pages (from-to)559-571
Number of pages13
JournalActa Ophthalmologica
Issue number6
StatePublished - 1 Sep 2020


  • mathematical modelling
  • normal tension glaucoma
  • ocular blood flow
  • primary open-angle glaucoma
  • retinal oximetry
  • retinal oxygen demand


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