TY - JOUR
T1 - Retinal nerve fiber layer thickness in children with optic pathway gliomas
AU - Avery, Robert A.
AU - Liu, Grant T.
AU - Fisher, Michael J.
AU - Quinn, Graham E.
AU - Belasco, Jean B.
AU - Phillips, Peter C.
AU - Maguire, Maureen G.
AU - Balcer, Laura J.
N1 - Funding Information:
Publication of this article was Supported by the National Institutes of Health/National Eye Institute Pediatric Research Loan repayment program , Bethesda, Maryland (Dr Avery); Grant 1T32NS061779-01 for the Neurologic Clinical Epidemiology Training Program (Laura Balcer, Principal Investigator) from the National Institutes of Health (Dr Avery); the Lynn Saligman League of the Children's Hospital of Philadelphia, Philadelphia, Pennsylvania (Dr Avery); and Grant K24 EY018136 from the National Eye Institute, National Institutes of Health (Drs Balcer and Maguire). Involved in Design of study (R.A.A., G.T.L., M.J.F., G.E.Q., M.G.M., L.J.B.); Conduct of study (R.A.A., G.T.L.); Collection, management, analysis, and interpretation of data (R.A.A., G.T.L., M.J.F., G.E.Q., J.B.B., P.C.P., M.G.M., L.J.B.); and Preparation, review, and approval of manuscript (R.A.A., G.T.L., M.J.F., G.E.Q., J.B.B., P.C.P., M.G.M., L.J.B.). This study was approved by the Children's Hospital of Philadelphia Institutional Review Board and was in accordance with Health Insurance Portability and Accountability Act regulations. Written consent for the study was obtained from the patients and or their legal guardian before study participation. The authors thank Dr Jean Bennett for the use of her optical coherence tomography device, Kathleen Marshall for technical advice with optical coherence tomography acquisition, and Angie Miller for help in subject recruitment.
PY - 2011/3
Y1 - 2011/3
N2 - • Purpose: To determine the relationship of high-contrast visual acuity (VA) and low-contrast letter acuity with retinal nerve fiber layer (RNFL) thickness in children with optic pathway gliomas. • Design: Cross-sectional convenience sample, with prospective data collection, from a tertiary care children's hospital of patients with optic pathway gliomas associated with neurofibromatosis type 1, sporadic optic pathway gliomas, and neurofibromatosis type 1 without optic pathway gliomas. • Methods: Patients underwent best-corrected VA testing using surrounded H, O, T, V optotypes and low-contrast letter acuity (5%, 2.5%, and 1.25% low-contrast Sloan letter charts). Mean RNFL thickness (micrometers) was measured by a Stratus optical coherence tomography device (Carl Zeiss Meditec) using the fast RNFL thickness protocol. Eyes were classified as having abnormal vision if they had high-contrast VA of more than 0.1 logarithm of the minimal angle of resolution units or visual field loss. The association of subject age, glioma location, and RNFL thickness with both VA and low-contrast letter acuity scores was evaluated by 1-way analysis of variance and linear regression, using the generalized estimating equation approach to account for within-patient intereye correlations. • Results: Eighty-nine eyes of patients with optic pathway gliomas were included, and 41 were classified as having abnormal VA or visual field loss. Reduced RNFL thickness was associated significantly with higher logarithm of the minimal angle of resolution scores for both VA (P < .001) and all low-contrast letter acuity charts (P < .001) when accounting for age and glioma location. • Conclusions: Eyes of most children with optic pathway gliomas and decreased RNFL thickness had abnormal VA or visual field loss.
AB - • Purpose: To determine the relationship of high-contrast visual acuity (VA) and low-contrast letter acuity with retinal nerve fiber layer (RNFL) thickness in children with optic pathway gliomas. • Design: Cross-sectional convenience sample, with prospective data collection, from a tertiary care children's hospital of patients with optic pathway gliomas associated with neurofibromatosis type 1, sporadic optic pathway gliomas, and neurofibromatosis type 1 without optic pathway gliomas. • Methods: Patients underwent best-corrected VA testing using surrounded H, O, T, V optotypes and low-contrast letter acuity (5%, 2.5%, and 1.25% low-contrast Sloan letter charts). Mean RNFL thickness (micrometers) was measured by a Stratus optical coherence tomography device (Carl Zeiss Meditec) using the fast RNFL thickness protocol. Eyes were classified as having abnormal vision if they had high-contrast VA of more than 0.1 logarithm of the minimal angle of resolution units or visual field loss. The association of subject age, glioma location, and RNFL thickness with both VA and low-contrast letter acuity scores was evaluated by 1-way analysis of variance and linear regression, using the generalized estimating equation approach to account for within-patient intereye correlations. • Results: Eighty-nine eyes of patients with optic pathway gliomas were included, and 41 were classified as having abnormal VA or visual field loss. Reduced RNFL thickness was associated significantly with higher logarithm of the minimal angle of resolution scores for both VA (P < .001) and all low-contrast letter acuity charts (P < .001) when accounting for age and glioma location. • Conclusions: Eyes of most children with optic pathway gliomas and decreased RNFL thickness had abnormal VA or visual field loss.
UR - https://www.scopus.com/pages/publications/79951810406
U2 - 10.1016/j.ajo.2010.08.046
DO - 10.1016/j.ajo.2010.08.046
M3 - Article
AN - SCOPUS:79951810406
SN - 0002-9394
VL - 151
SP - 542-549.e2
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
IS - 3
ER -