Retinal insulin receptors. 2. Characterization and insulininduced tyrosine kinase activity in bovine retinal rod outer segments

Robert J. Waldbillig; R. Theodore Fletcher; Gerald J. Chader; Sankaran Rajagopalan; Merlyn Rodrigues; D. LeRoith

doi:10.1016/S0014-4835(87)80100-8

Retinal insulin receptors. 2. Characterization and insulininduced tyrosine kinase activity in bovine retinal rod outer segments

Robert J. Waldbillig, R. Theodore Fletcher, Gerald J. Chader, Sankaran Rajagopalan, Merlyn Rodrigues, D. LeRoith

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Bovine retinal rod outer segments (ROS) possess specific, high-affinity receptors for insulin. These receptors exhibit an insulin-stimulatable tyrosine-specific activity that is capable of phosphorylating the receptor's own β-subunit and exogenous substrate. ROS insulin receptors exhibit heterogeneity in the apparent molecular weight of the receptor's α-subunit. In this regard, insulin receptors from this single cell type resemble insulin receptors obtained from whole retina, but are unlike receptors from brain and liver.

Original language	English
Pages (from-to)	837-844
Number of pages	8
Journal	Experimental Eye Research
Volume	45
Issue number	6
DOIs	https://doi.org/10.1016/S0014-4835(87)80100-8
State	Published - Dec 1987
Externally published	Yes

Keywords

autophosphorylation
insulin receptors
retina
rod outer segments
tyrosine kinase

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10.1016/S0014-4835(87)80100-8

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title = "Retinal insulin receptors. 2. Characterization and insulininduced tyrosine kinase activity in bovine retinal rod outer segments",

abstract = "Bovine retinal rod outer segments (ROS) possess specific, high-affinity receptors for insulin. These receptors exhibit an insulin-stimulatable tyrosine-specific activity that is capable of phosphorylating the receptor's own β-subunit and exogenous substrate. ROS insulin receptors exhibit heterogeneity in the apparent molecular weight of the receptor's α-subunit. In this regard, insulin receptors from this single cell type resemble insulin receptors obtained from whole retina, but are unlike receptors from brain and liver.",

keywords = "autophosphorylation, insulin receptors, retina, rod outer segments, tyrosine kinase",

author = "Waldbillig, {Robert J.} and Fletcher, {R. Theodore} and Chader, {Gerald J.} and Sankaran Rajagopalan and Merlyn Rodrigues and D. LeRoith",

year = "1987",

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T1 - Retinal insulin receptors. 2. Characterization and insulininduced tyrosine kinase activity in bovine retinal rod outer segments

AU - Waldbillig, Robert J.

AU - Fletcher, R. Theodore

AU - Chader, Gerald J.

AU - Rajagopalan, Sankaran

AU - Rodrigues, Merlyn

AU - LeRoith, D.

PY - 1987/12

Y1 - 1987/12

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AB - Bovine retinal rod outer segments (ROS) possess specific, high-affinity receptors for insulin. These receptors exhibit an insulin-stimulatable tyrosine-specific activity that is capable of phosphorylating the receptor's own β-subunit and exogenous substrate. ROS insulin receptors exhibit heterogeneity in the apparent molecular weight of the receptor's α-subunit. In this regard, insulin receptors from this single cell type resemble insulin receptors obtained from whole retina, but are unlike receptors from brain and liver.

KW - autophosphorylation

KW - insulin receptors

KW - retina

KW - rod outer segments

KW - tyrosine kinase

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U2 - 10.1016/S0014-4835(87)80100-8

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JO - Experimental Eye Research

JF - Experimental Eye Research

IS - 6

ER -

Retinal insulin receptors. 2. Characterization and insulininduced tyrosine kinase activity in bovine retinal rod outer segments

Abstract

Keywords

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