TY - JOUR
T1 - Retinal ganglion cell layer thinning within one month of presentation for optic neuritis
AU - Kupersmith, Mark J.
AU - Garvin, Mona K.
AU - Wang, Jui Kai
AU - Durbin, Mary
AU - Kardon, Randy
N1 - Funding Information:
This work was supported, in part, by 3U10EY01728104AS1, NEI subcontract R009040554, NEI R01 EY018853, R01 EY023279, the Department of Veterans Affairs Rehabilitation Research and Development Division (Iowa City Center for the Prevention and Treatment of Visual Loss and Career Development Award 1IK2RX000728 for Dr Garvin), and Research to Prevent Blindness (New York, USA).
Publisher Copyright:
© SAGE Publications.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background: Spectral domain optical coherence tomography (SD-OCT) reveals retinal ganglion cell layer plus inner plexiform layer (GCL+IPL) and peripapillary retinal nerve fiber layer (pRNFL) thinning in chronic optic nerve injury. At presentation, swelling of the pRNFL confounds evaluation of early axon loss. Objective: We studied whether the GCL+IPL thins before the pRNFL, the trajectory of GCL+IPL loss and relationship to vision. Methods: We prospectively evaluated 33 eyes (study) with new optic neuritis, using perimetry and SD-OCT with investigative three-dimensional layer segmentation and commercial two-dimensional segmentation to compute the GCL+IPL and pRNFL thickness. Results: At presentation, GCL+IPL thickness (82.4±8.8 μm) did not differ from unaffected fellow eyes (81.2±6.7 μm), via the three-dimensional method, while the two-dimensional method failed in 9% of study eyes. At 1-2 months, there was thinning of the pRNFL in 10% and of the GCL+IPL in 93% of study eyes. GCL+IPL reduction was greatest during the first 2 months. GCL+IPL thinning at 1-2 months correlated with GCL+IPL thinning at 6 months (r=0.84, P=0.01) and presentation visual acuity (r=0.48, P=0.006) and perimetric mean deviation (r=0.52, P=0.003). Conclusion: GGL+IPL is an early biomarker of structural injury in optic neuritis as thinning develops within 1-2 months of onset, prior to pRNFL thinning.
AB - Background: Spectral domain optical coherence tomography (SD-OCT) reveals retinal ganglion cell layer plus inner plexiform layer (GCL+IPL) and peripapillary retinal nerve fiber layer (pRNFL) thinning in chronic optic nerve injury. At presentation, swelling of the pRNFL confounds evaluation of early axon loss. Objective: We studied whether the GCL+IPL thins before the pRNFL, the trajectory of GCL+IPL loss and relationship to vision. Methods: We prospectively evaluated 33 eyes (study) with new optic neuritis, using perimetry and SD-OCT with investigative three-dimensional layer segmentation and commercial two-dimensional segmentation to compute the GCL+IPL and pRNFL thickness. Results: At presentation, GCL+IPL thickness (82.4±8.8 μm) did not differ from unaffected fellow eyes (81.2±6.7 μm), via the three-dimensional method, while the two-dimensional method failed in 9% of study eyes. At 1-2 months, there was thinning of the pRNFL in 10% and of the GCL+IPL in 93% of study eyes. GCL+IPL reduction was greatest during the first 2 months. GCL+IPL thinning at 1-2 months correlated with GCL+IPL thinning at 6 months (r=0.84, P=0.01) and presentation visual acuity (r=0.48, P=0.006) and perimetric mean deviation (r=0.52, P=0.003). Conclusion: GGL+IPL is an early biomarker of structural injury in optic neuritis as thinning develops within 1-2 months of onset, prior to pRNFL thinning.
KW - OCT
KW - RNFL
KW - Retinal ganglion cell layer
KW - optic neuritis
KW - peripapillary retinal nerve fiber layer
UR - http://www.scopus.com/inward/record.url?scp=85016197659&partnerID=8YFLogxK
U2 - 10.1177/1352458515598020
DO - 10.1177/1352458515598020
M3 - Article
C2 - 26362894
AN - SCOPUS:85016197659
SN - 1352-4585
VL - 22
SP - 641
EP - 648
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 5
ER -