Reticulocyte protein synthesis: Response of ribosome fractions to polyuridylic acid

I. Bernard Weinstein; Alan N. Schechter; Edward R. Burka; Paul A. Marks

doi:10.1126/science.140.3564.314

Reticulocyte protein synthesis: Response of ribosome fractions to polyuridylic acid

I. Bernard Weinstein, Alan N. Schechter, Edward R. Burka, Paul A. Marks

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Reticulocyte ribosomes with sedimentation coefficients greater than 100S ("heavy" ribosomes) appear to be considerably more active in hemoglobin synthesis than are 78S ribosomes. When assayed for the ability to synthesize polyphenylalanine in the presence of polyuridylic acid, the 78S ribosomes and "heavy" ribosomes have similar activities. Polyuridylic acid inhibits incorporation by "heavy" ribosomes of amino acids other than phenylalanine.

Original language	English
Pages (from-to)	314-316
Number of pages	3
Journal	Science
Volume	140
Issue number	3564
DOIs	https://doi.org/10.1126/science.140.3564.314
State	Published - 1963
Externally published	Yes

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title = "Reticulocyte protein synthesis: Response of ribosome fractions to polyuridylic acid",

abstract = "Reticulocyte ribosomes with sedimentation coefficients greater than 100S ({"}heavy{"} ribosomes) appear to be considerably more active in hemoglobin synthesis than are 78S ribosomes. When assayed for the ability to synthesize polyphenylalanine in the presence of polyuridylic acid, the 78S ribosomes and {"}heavy{"} ribosomes have similar activities. Polyuridylic acid inhibits incorporation by {"}heavy{"} ribosomes of amino acids other than phenylalanine.",

author = "{Bernard Weinstein}, I. and Schechter, {Alan N.} and Burka, {Edward R.} and Marks, {Paul A.}",

year = "1963",

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AU - Bernard Weinstein, I.

AU - Schechter, Alan N.

AU - Burka, Edward R.

AU - Marks, Paul A.

PY - 1963

Y1 - 1963

N2 - Reticulocyte ribosomes with sedimentation coefficients greater than 100S ("heavy" ribosomes) appear to be considerably more active in hemoglobin synthesis than are 78S ribosomes. When assayed for the ability to synthesize polyphenylalanine in the presence of polyuridylic acid, the 78S ribosomes and "heavy" ribosomes have similar activities. Polyuridylic acid inhibits incorporation by "heavy" ribosomes of amino acids other than phenylalanine.

AB - Reticulocyte ribosomes with sedimentation coefficients greater than 100S ("heavy" ribosomes) appear to be considerably more active in hemoglobin synthesis than are 78S ribosomes. When assayed for the ability to synthesize polyphenylalanine in the presence of polyuridylic acid, the 78S ribosomes and "heavy" ribosomes have similar activities. Polyuridylic acid inhibits incorporation by "heavy" ribosomes of amino acids other than phenylalanine.

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U2 - 10.1126/science.140.3564.314

DO - 10.1126/science.140.3564.314

M3 - Article

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AN - SCOPUS:37049229139

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VL - 140

SP - 314

EP - 316

JO - Science

JF - Science

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ER -

Reticulocyte protein synthesis: Response of ribosome fractions to polyuridylic acid

Abstract

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