Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity

Pauline Rimmelé, Sébastien Lofek-Czubek, Saghi Ghaffari

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Resveratrol is a plant-derived polyphenol that has shown protective effects against many disorders including, several types of cancers and other age-associated diseases as well as blood disorders in cultured cells and/or animal models. However, whether resveratrol has any impact specifically on normal blood stem cells remains unknown. Here, we show that a 3-week treatment of resveratrol increases the frequency and total numbers of normal bone marrow hematopoietic stem cells (HSC) without any impact on their competitive repopulation capacity. In addition, we show that resveratrol enhances the bone marrow multipotent progenitor capacity in vivo. These results have therapeutic value for disorders of hematopoietic stem and progenitor cells (HSPC) as well as for bone marrow transplantation settings.

Original languageEnglish
Pages (from-to)E235-E238
JournalAmerican Journal of Hematology
Issue number12
StatePublished - 1 Dec 2014


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