Resveratrol in human cancer chemoprevention - choosing the 'right' dose

Edwina Scott, William P. Steward, Andreas J. Gescher, Karen Brown

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations

Abstract

There is now robust preclinical evidence to suggest that resveratrol possesses cancer chemopreventive properties. A series of clinical pilot studies has provided insights into its pharmacokinetics, and data on its human antineoplastic pharmacodynamics start to emerge. It is likely that resveratrol will be developed further in the clinic as a putative cancer chemopreventive agent. The question that remains unresolved is: What is the most suitable dose of resveratrol for effective cancer preventive intervention? Mechanistic studies in cells in vitro have almost invariably used concentrations of resveratrol in the 10 -5 to 10 -4M range, which is much higher than those which can be achieved in the human biophase after consumption of doses up to 1g. Many of the preclinical efficacy studies in rodent models of carcinogenesis have employed doses which are dramatically above those which can be ingested with the diet. New experimental paradigms need to be used to obtain information on pharmacological changes elicited by resveratrol when present at very low concentrations or when administered at dietary-relevant doses.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalMolecular Nutrition and Food Research
Volume56
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Keywords

  • Cancer chemoprevention
  • Dose
  • Pharmacodynamics
  • Pharmacokinetics
  • Resveratrol

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