TY - JOUR
T1 - Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk
T2 - A systematic review
AU - Innes, Kim E.
AU - Selfe, Terry Kit
AU - Agarwal, Parul
N1 - Funding Information:
This work was made possible by the National Center for Complementary and Alternative Medicine and the Office of Research on Women's Health (Grant Numbers R21AT002982 and 1K01 AT004108 to KEI), the University of Virginia, and West Virginia University. We wish to thank Dr. Somu Chatterjee for his valuable assistance with the literature search and table preparation. The contents are solely the responsibility of the authors and do not represent the official views of West Virginia University, the University of Virginia, or the National Institutes of Health.
PY - 2012/8
Y1 - 2012/8
N2 - Restless legs syndrome (RLS) is a distressing sleep and sensorimotor disorder that affects a large percentage of adults in the western industrialized world and is associated with profound reductions in quality of life. However, the etiology of RLS remains incompletely understood. Enhanced understanding regarding both the antecedents and sequelae of RLS could shed new light on the pathogenesis of RLS. Evidence from an emerging body of literature suggests associations between RLS and diabetes, hypertension, obesity, and related conditions linked to sympathetic activation and metabolic dysregulation, raising the possibility that these factors may likewise play a significant role in the development and progression of RLS, and could help explain the recently documented associations between RLS and subsequent cardiovascular disease. However, the relation between RLS and these chronic conditions has received relatively little attention to date, although potential implications for the pathogenesis and treatment of RLS could be considerable. In this paper, we systematically review the recently published literature regarding the association of RLS to cardiovascular disease and related risk factors characterized by sympathoadrenal and metabolic dysregulation, discuss potential underlying mechanisms, and outline some possible directions for future research.
AB - Restless legs syndrome (RLS) is a distressing sleep and sensorimotor disorder that affects a large percentage of adults in the western industrialized world and is associated with profound reductions in quality of life. However, the etiology of RLS remains incompletely understood. Enhanced understanding regarding both the antecedents and sequelae of RLS could shed new light on the pathogenesis of RLS. Evidence from an emerging body of literature suggests associations between RLS and diabetes, hypertension, obesity, and related conditions linked to sympathetic activation and metabolic dysregulation, raising the possibility that these factors may likewise play a significant role in the development and progression of RLS, and could help explain the recently documented associations between RLS and subsequent cardiovascular disease. However, the relation between RLS and these chronic conditions has received relatively little attention to date, although potential implications for the pathogenesis and treatment of RLS could be considerable. In this paper, we systematically review the recently published literature regarding the association of RLS to cardiovascular disease and related risk factors characterized by sympathoadrenal and metabolic dysregulation, discuss potential underlying mechanisms, and outline some possible directions for future research.
KW - Autonomic dysfunction
KW - Cardiovascular disease
KW - Diabetes
KW - Dyslipidemia
KW - Ekbom disease
KW - HPA axis dysfunction
KW - Hypertension
KW - Impaired glucose tolerance
KW - Obesity
KW - RLS
KW - Restless legs syndrome
KW - Weight gain
UR - http://www.scopus.com/inward/record.url?scp=84861760091&partnerID=8YFLogxK
U2 - 10.1016/j.smrv.2011.04.001
DO - 10.1016/j.smrv.2011.04.001
M3 - Review article
C2 - 21733722
AN - SCOPUS:84861760091
SN - 1087-0792
VL - 16
SP - 309
EP - 339
JO - Sleep Medicine Reviews
JF - Sleep Medicine Reviews
IS - 4
ER -