Resting state executive control network adaptations in amnestic mild cognitive impairment

Liyong Wu, Ricardo Bernardi Soder, Dorothée Schoemaker, Felix Carbonnell, Viviane Sziklas, Jared Rowley, Sara Mohades, Vladmir Fonov, Pierre Bellec, Alain Dagher, Amir Shmuel, Jianping Jia, Serge Gauthier, Pedro Rosa-Neto

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Executive dysfunction is frequently associated with episodic memory decline in amnestic mild cognitive impairment (aMCI) patients. Resting state executive control network (RS-ECN) represents a novel approach to interrogate the integrity of brain areas underlying executive dysfunction. The present study aims to investigate RS-ECN in aMCI and examine a possible link between changes in brain functional connectivity and declines in executive function. aMCI individuals (n = 13) and healthy subjects (n = 16) underwent cognitive assessment including executive function and high field functional magnetic resonance imaging. Individual RS-ECN maps were estimated using a seed-based cross-correlation method. Between groups RS-ECN functional connectivity comparison was assessed using voxel-wise statistic parametric mapping. aMCI individuals had reduced RS-ECN connectivity in the anterior cingulate cortex (ACC) and dorsal lateral prefrontal cortex (DLPFC), bilaterally. In contrast, aMCI showed increased connectivity in ventral lateral and anterior prefrontal cortex, bilaterally. Connectivity strength was associated with executive function in the ACC (r = 0.6213, p = 0.023) and right DLPFC (r = 0.6454, p = 0.017). Coexistence between connectivity declines and recruitment of brain regions outside the RS-ECN as reported here fits a brain reserve conceptual framework in which brain networks undergo remodeling in aMCI individuals.

Original languageEnglish
Pages (from-to)993-1004
Number of pages12
JournalJournal of Alzheimer's Disease
Issue number4
StatePublished - 2014
Externally publishedYes


  • Executive control network
  • executive function
  • functional MRI
  • mild cognitive impairment
  • neural plasticity


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