Responsive neurostimulation for regional neocortical epilepsy

Brandy B. Ma, Madeline C. Fields, Robert C. Knowlton, Edward F. Chang, Jerzy P. Szaflarski, Lara V. Marcuse, Vikram R. Rao

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Objective: Surgical resection of seizure-producing brain tissue is a gold standard treatment for drug-resistant focal epilepsy. However, several patient-specific factors can preclude resective surgery, including a spatially extensive (“regional”) seizure-onset zone (SOZ). For such patients, responsive neurostimulation (RNS) represents a potential treatment, but its efficacy has not been investigated in this population. Methods: We performed a multicenter retrospective cohort study of patients (N = 30) with drug-resistant focal epilepsy and a regional neocortical SOZ delineated by intracranial monitoring who were treated with the RNS System for at least 6 months. RNS System leads were placed at least 1-cm apart over the SOZ, and most patients were treated with a lead-to-lead stimulation pathway. Five patients underwent partial resection of the SOZ concurrent with RNS System implantation. We assessed change in seizure frequency relative to preimplant baseline and evaluated correlation between clinical outcome and stimulation parameters. Results: Median follow-up duration was 21.5 months (range 6-52). Median reduction in clinical seizure frequency was 75.5% (interquartile range [IQR] 40%-93.9%). There was no significant difference in outcome between patients treated with and without concurrent partial resection. Most patients were treated with low charge densities (1-2.5 µC/cm2), but charge density, interlead distance, and duration of treatment were not significantly correlated with outcome. Significance: RNS is a feasible and effective treatment in patients with drug-resistant regional neocortical seizures. Prospective studies in larger cohorts are necessary to determine optimal lead configuration and stimulation parameters, although our results suggest that lead-to-lead stimulation and low charge density may be effective in some patients.

Original languageEnglish
Pages (from-to)96-106
Number of pages11
Issue number1
StatePublished - 1 Jan 2020


  • drug-resistant epilepsy; RNS System; responsive neurostimulation; regional neocortical seizures


Dive into the research topics of 'Responsive neurostimulation for regional neocortical epilepsy'. Together they form a unique fingerprint.

Cite this