Responsive Hydrogels Based on Triggered Click Reactions for Liver Cancer

Jia Qi Zhu, Han Wu, Zhen Li Li, Xin Fei Xu, Hao Xing, Ming Da Wang, Hang Dong Jia, Lei Liang, Chao Li, Li Yang Sun, Yu Guang Wang, Feng Shen, Dong Sheng Huang, Tian Yang

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Globally, liver cancer, which is one of the major cancers worldwide, has attracted the growing attention of technological researchers for its high mortality and limited treatment options. Hydrogels are soft 3D network materials containing a large number of hydrophilic monomers. By adding moieties such as nitrobenzyl groups to the network structure of a cross-linked nanocomposite hydrogel, the click reaction improves drug-release efficiency in vivo, which improves the survival rate and prolongs the survival time of liver cancer patients. The application of a nanocomposite hydrogel drug delivery system can not only enrich the drug concentration at the tumor site for a long time but also effectively prevents the distant metastasis of residual tumor cells. At present, a large number of researches have been working toward the construction of responsive nanocomposite hydrogel drug delivery systems, but there are few comprehensive articles to systematically summarize these discoveries. Here, this systematic review summarizes the synthesis methods and related applications of nanocomposite responsive hydrogels with actions to external or internal physiological stimuli. With different physical or chemical stimuli, the structural unit rearrangement and the controlled release of drugs can be used for responsive drug delivery in different states.

Original languageEnglish
Article number2201651
JournalAdvanced Materials
Issue number38
StatePublished - 22 Sep 2022
Externally publishedYes


  • click chemistry
  • liver cancer
  • nanoparticle–hydrogel hybrids
  • polymers
  • stimuli-responsive materials


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