Response to suxamethonium in a myasthenic patient during remission

M. ABEL; J. B. EISENKRAFT; N. PATEL

doi:10.1111/j.1365-2044.1991.tb09310.x

Response to suxamethonium in a myasthenic patient during remission

M. ABEL, J. B. EISENKRAFT, N. PATEL

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed my asthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED₅₀ and ED₉₀ values for suxamethonium were 0.08mg/kg and 0.20mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90–95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.

Original language	English
Pages (from-to)	30-32
Number of pages	3
Journal	Anaesthesia
Volume	46
Issue number	1
DOIs	https://doi.org/10.1111/j.1365-2044.1991.tb09310.x
State	Published - Jan 1991

Keywords

Complications; myasthenia gravis
Measurement techniques; electromyography, neuromuscular blockade
Neuromuscular relaxants; suxamethonium

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10.1111/j.1365-2044.1991.tb09310.x

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title = "Response to suxamethonium in a myasthenic patient during remission",

abstract = "A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed my asthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08mg/kg and 0.20mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90–95\% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.",

keywords = "Complications; myasthenia gravis, Measurement techniques; electromyography, neuromuscular blockade, Neuromuscular relaxants; suxamethonium",

author = "M. ABEL and EISENKRAFT, \{J. B.\} and N. PATEL",

year = "1991",

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AU - ABEL, M.

AU - EISENKRAFT, J. B.

AU - PATEL, N.

PY - 1991/1

Y1 - 1991/1

N2 - A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed my asthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08mg/kg and 0.20mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90–95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.

AB - A cumulative dose followed by an infusion was used to determine the dose response to suxamethonium in a patient with diagnosed my asthenia gravis who was in true remission (asymptomatic while receiving no therapy). The ED50 and ED90 values for suxamethonium were 0.08mg/kg and 0.20mg/kg, and an infusion rate of 3.2 mg/kg/hour was required to maintain a 90–95% depression of the single twitch response as monitored by integrated electromyography. These values are within the range for normal patients, and we conclude that myasthenic patients during a true remission may not demonstrate resistance to suxamethonium.

KW - Complications; myasthenia gravis

KW - Measurement techniques; electromyography, neuromuscular blockade

KW - Neuromuscular relaxants; suxamethonium

UR - https://www.scopus.com/pages/publications/0025959302

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AN - SCOPUS:0025959302

SN - 0003-2409

VL - 46

SP - 30

EP - 32

JO - Anaesthesia

JF - Anaesthesia

IS - 1

ER -

Response to suxamethonium in a myasthenic patient during remission

Abstract

Keywords

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