Response to granulocyte colony-stimulating factor in an autoimmune neutropenic adult

Shion Imoto; Makoto Hashimoto; Mitsuko Miyamoto; Tohru Murayama; Mika Murayama; Masanori Nakamura; Toshimitsu Matsui; Kazuo Chihara; Ryukichi Ryo

doi:10.1159/000040943

Response to granulocyte colony-stimulating factor in an autoimmune neutropenic adult

Shion Imoto, Makoto Hashimoto, Mitsuko Miyamoto, Tohru Murayama, Mika Murayama, Masanori Nakamura, Toshimitsu Matsui, Kazuo Chihara, Ryukichi Ryo

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Clinical value of granulocyte colony-stimulating factor (G-CSF) for autoimmune neutropenia (AIN) has not been well established. We experienced an adult case of AIN which showed an excellent response to G-CSF. A 75-year-old female was admitted with high-grade fever. Her neutrophil count was remarkably low (neutrophil 0.09 x 10⁹/l). Antigranulocyte autoantibody was demonstrated in her serum by an immunofluorescence method and she was diagnosed as AIN. Administration of G-CSF (filgrastim 5 μg/kg) gave a rapid increase of neutrophils (from O.11 x 10⁹/l to 2.10 x 10⁹/l on the second day), which has enabled us to preserve the use of G-CSF for emergency, that is, for overt serious infection.

Original language	English
Pages (from-to)	153-156
Number of pages	4
Journal	Acta Haematologica
Volume	101
Issue number	3
DOIs	https://doi.org/10.1159/000040943
State	Published - 1999

Keywords

Anti-granulocyte autoantibody
Autoimmune neutropenia
Granulocyte colony-stimulating factor

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10.1159/000040943

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title = "Response to granulocyte colony-stimulating factor in an autoimmune neutropenic adult",

abstract = "Clinical value of granulocyte colony-stimulating factor (G-CSF) for autoimmune neutropenia (AIN) has not been well established. We experienced an adult case of AIN which showed an excellent response to G-CSF. A 75-year-old female was admitted with high-grade fever. Her neutrophil count was remarkably low (neutrophil 0.09 x 109/l). Antigranulocyte autoantibody was demonstrated in her serum by an immunofluorescence method and she was diagnosed as AIN. Administration of G-CSF (filgrastim 5 μg/kg) gave a rapid increase of neutrophils (from O.11 x 109/l to 2.10 x 109/l on the second day), which has enabled us to preserve the use of G-CSF for emergency, that is, for overt serious infection.",

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AU - Imoto, Shion

AU - Hashimoto, Makoto

AU - Miyamoto, Mitsuko

AU - Murayama, Tohru

AU - Murayama, Mika

AU - Nakamura, Masanori

AU - Matsui, Toshimitsu

AU - Chihara, Kazuo

AU - Ryo, Ryukichi

PY - 1999

Y1 - 1999

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AB - Clinical value of granulocyte colony-stimulating factor (G-CSF) for autoimmune neutropenia (AIN) has not been well established. We experienced an adult case of AIN which showed an excellent response to G-CSF. A 75-year-old female was admitted with high-grade fever. Her neutrophil count was remarkably low (neutrophil 0.09 x 109/l). Antigranulocyte autoantibody was demonstrated in her serum by an immunofluorescence method and she was diagnosed as AIN. Administration of G-CSF (filgrastim 5 μg/kg) gave a rapid increase of neutrophils (from O.11 x 109/l to 2.10 x 109/l on the second day), which has enabled us to preserve the use of G-CSF for emergency, that is, for overt serious infection.

KW - Anti-granulocyte autoantibody

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KW - Granulocyte colony-stimulating factor

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Response to granulocyte colony-stimulating factor in an autoimmune neutropenic adult

Abstract

Keywords

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