Response of the rat aortic wall to hypertension: Importance of comparing absolute amounts of wall components

H. Wolinsky

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

The amounts of elastin and collagen in identical segments of thoracic aortas of normotensive and hypertensive male rats were compared. The absolute amounts of elastin and collagen were significantly increased in vessels from hypertensive animals; however, the relative amounts (percentages) of elastin and total fibrous protein were not significantly different. When indisputable evidence for a net change in the amount of a tissue component is desired, it is imperative to compare absolute amounts of that component in denticial, anatomically-defined tissue samples.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalAtherosclerosis
Volume11
Issue number2
DOIs
StatePublished - 1970
Externally publishedYes

Keywords

  • Aorta
  • Collagen
  • Elastin
  • Hypertension

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