Response of Legionella pneumophila to β-lactam antibiotics

S. Weisholtz, A. Tomasz

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Legionella pneumophila Philadelphia strain 1 grown in vitro contained five penicillin-binding proteins that were accessible to the antibiotic in membrane preparations and in live cells as well. The bacterium had reasonably low MICs of several β-lactam antibiotics and was susceptible to both the bactericidal and the lytic activity of these drugs. An unusual feature of the response of this bacterium to penicillin treatment was that cell lysis as determined by decrease in culture turbidity and release of intracellular macromolecules was not accompanied by degradation of the peptidoglycan.

Original languageEnglish
Pages (from-to)695-700
Number of pages6
JournalAntimicrobial Agents and Chemotherapy
Issue number5
StatePublished - 1985
Externally publishedYes


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