TY - JOUR
T1 - Respiratory and glycemic control outcomes of late preterm infants after antenatal corticosteroid exposure
AU - Janssen, Olivia
AU - Ratner, Veniamin
AU - Lin, Jing
AU - Fox, Nathan
AU - Green, Robert
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/11
Y1 - 2021/11
N2 - Objective: To quantify changes in respiratory and glycemic control outcomes following antenatal corticosteroids (ANCS) exposure in late preterm neonates. Design/Methods: The study included 500 neonates born between 34 0/7 and 36 6/7 weeks of gestation. Study population was divided into two groups: an immature group (34 0/7–35 6/7 weeks) and a mature group (36 0/7–36 6/7 weeks). Respiratory and glycemic control outcomes were analyzed for each group independently. Results: In the immature group, the odds of developing respiratory distress decreased in neonates exposed to ANCS within 7 days of delivery (aOR 0.42; p = 0.02). In the mature group, ANCS exposure did not change respiratory outcomes, but decreased lowest blood glucose levels (−1.5 ± 0.66 mg/dL per dose, p = 0.02). Conclusion: In our study cohort, ANCS administration was associated with improved neonatal respiratory outcomes only for infants in the immature 34 0/7–35 6/7 weeks of gestational age group. ANCS was associated with altered glycemic control only in infants in the mature 36 0/7–36 6/7 weeks of gestational age group.
AB - Objective: To quantify changes in respiratory and glycemic control outcomes following antenatal corticosteroids (ANCS) exposure in late preterm neonates. Design/Methods: The study included 500 neonates born between 34 0/7 and 36 6/7 weeks of gestation. Study population was divided into two groups: an immature group (34 0/7–35 6/7 weeks) and a mature group (36 0/7–36 6/7 weeks). Respiratory and glycemic control outcomes were analyzed for each group independently. Results: In the immature group, the odds of developing respiratory distress decreased in neonates exposed to ANCS within 7 days of delivery (aOR 0.42; p = 0.02). In the mature group, ANCS exposure did not change respiratory outcomes, but decreased lowest blood glucose levels (−1.5 ± 0.66 mg/dL per dose, p = 0.02). Conclusion: In our study cohort, ANCS administration was associated with improved neonatal respiratory outcomes only for infants in the immature 34 0/7–35 6/7 weeks of gestational age group. ANCS was associated with altered glycemic control only in infants in the mature 36 0/7–36 6/7 weeks of gestational age group.
UR - http://www.scopus.com/inward/record.url?scp=85110981585&partnerID=8YFLogxK
U2 - 10.1038/s41372-021-01162-y
DO - 10.1038/s41372-021-01162-y
M3 - Article
C2 - 34290375
AN - SCOPUS:85110981585
SN - 0743-8346
VL - 41
SP - 2607
EP - 2613
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 11
ER -