Resolution of immune activation defines nonpathogenic SIV infection

Olivier Manches, Nina Bhardwaj

Research output: Contribution to journalComment/debate

34 Scopus citations


Natural nonhuman primate hosts of SIV do not succumb to AIDS despite significant viral replication, a phenomenon attributed to reduced levels of chronic and deleterious "immune activation." Two studies in this issue of the JCI, by Bosinger et al. and Jacquelin et al., now show that SIV induces vigorous immune activation and upregulation of IFN-stimulated genes in both natural and susceptible hosts, but strikingly, the responses resolve only in the former (see the related articles beginning on pages 3556 and 3544, respectively). Thus, natural hosts for SIV actively engage mechanisms to abort sustained immune activation and its associated harmful effects.

Original languageEnglish
Pages (from-to)3512-3515
Number of pages4
JournalJournal of Clinical Investigation
Issue number12
StatePublished - 1 Dec 2009
Externally publishedYes


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