Research advances in relationship between chemokine receptor-4/chemokine ligand-12 axis and development of gastric cancer

Jin Wang; Yi Chen Wang; Yuan Hu; Ping Liu; Xian Zhe Dong

doi:10.3867/j.issn.1000-3002.2019.12.009

Research advances in relationship between chemokine receptor-4/chemokine ligand-12 axis and development of gastric cancer

Jin Wang, Yi Chen Wang, Yuan Hu, Ping Liu, Xian Zhe Dong

Research output: Contribution to journal › Article › peer-review

Abstract

A few studies have shown that the chemokine receptor-4/chemokine ligand-12 (CXCR4/CXCL12) axis is closely related to the development of gastric cancer. The CXCR4/CXCL12 axis and its related signal pathways, including Janus protein tyrosine kinase 2/signal transduction and transcription activator 3 and phosphatidylinositol-3/kinase-protein kinase B/mammalian target of Rapamycin, and their related signal molecules, including epithelial-mechanism transition proto-oncogene, phosphoglyc-erate kinase 1, and dopamine and cAMP-regulated phosphoprotein, have effects on gastric cancer. Moreover, there are antagonists and some drugs that inhibit the involvement of the CXCR4/CXCL12 axis in regulating the development of gastric cancer.

Original language	English
Pages (from-to)	1078-1084
Number of pages	7
Journal	Chinese Journal of Pharmacology and Toxicology
Volume	33
Issue number	12
DOIs	https://doi.org/10.3867/j.issn.1000-3002.2019.12.009
State	Published - Dec 2019
Externally published	Yes

Keywords

Chemokine ligand-12
Chemokine receptor-4
Gastric cancer
Targeted inhibition

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10.3867/j.issn.1000-3002.2019.12.009

Cite this

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title = "Research advances in relationship between chemokine receptor-4/chemokine ligand-12 axis and development of gastric cancer",

abstract = "A few studies have shown that the chemokine receptor-4/chemokine ligand-12 (CXCR4/CXCL12) axis is closely related to the development of gastric cancer. The CXCR4/CXCL12 axis and its related signal pathways, including Janus protein tyrosine kinase 2/signal transduction and transcription activator 3 and phosphatidylinositol-3/kinase-protein kinase B/mammalian target of Rapamycin, and their related signal molecules, including epithelial-mechanism transition proto-oncogene, phosphoglyc-erate kinase 1, and dopamine and cAMP-regulated phosphoprotein, have effects on gastric cancer. Moreover, there are antagonists and some drugs that inhibit the involvement of the CXCR4/CXCL12 axis in regulating the development of gastric cancer.",

keywords = "Chemokine ligand-12, Chemokine receptor-4, Gastric cancer, Targeted inhibition",

author = "Jin Wang and Wang, \{Yi Chen\} and Yuan Hu and Ping Liu and Dong, \{Xian Zhe\}",

year = "2019",

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doi = "10.3867/j.issn.1000-3002.2019.12.009",

language = "English",

volume = "33",

pages = "1078--1084",

journal = "Chinese Journal of Pharmacology and Toxicology",

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TY - JOUR

T1 - Research advances in relationship between chemokine receptor-4/chemokine ligand-12 axis and development of gastric cancer

AU - Wang, Jin

AU - Wang, Yi Chen

AU - Hu, Yuan

AU - Liu, Ping

AU - Dong, Xian Zhe

PY - 2019/12

Y1 - 2019/12

N2 - A few studies have shown that the chemokine receptor-4/chemokine ligand-12 (CXCR4/CXCL12) axis is closely related to the development of gastric cancer. The CXCR4/CXCL12 axis and its related signal pathways, including Janus protein tyrosine kinase 2/signal transduction and transcription activator 3 and phosphatidylinositol-3/kinase-protein kinase B/mammalian target of Rapamycin, and their related signal molecules, including epithelial-mechanism transition proto-oncogene, phosphoglyc-erate kinase 1, and dopamine and cAMP-regulated phosphoprotein, have effects on gastric cancer. Moreover, there are antagonists and some drugs that inhibit the involvement of the CXCR4/CXCL12 axis in regulating the development of gastric cancer.

AB - A few studies have shown that the chemokine receptor-4/chemokine ligand-12 (CXCR4/CXCL12) axis is closely related to the development of gastric cancer. The CXCR4/CXCL12 axis and its related signal pathways, including Janus protein tyrosine kinase 2/signal transduction and transcription activator 3 and phosphatidylinositol-3/kinase-protein kinase B/mammalian target of Rapamycin, and their related signal molecules, including epithelial-mechanism transition proto-oncogene, phosphoglyc-erate kinase 1, and dopamine and cAMP-regulated phosphoprotein, have effects on gastric cancer. Moreover, there are antagonists and some drugs that inhibit the involvement of the CXCR4/CXCL12 axis in regulating the development of gastric cancer.

KW - Chemokine ligand-12

KW - Chemokine receptor-4

KW - Gastric cancer

KW - Targeted inhibition

UR - https://www.scopus.com/pages/publications/85101840602

U2 - 10.3867/j.issn.1000-3002.2019.12.009

DO - 10.3867/j.issn.1000-3002.2019.12.009

M3 - Article

AN - SCOPUS:85101840602

SN - 1000-3002

VL - 33

SP - 1078

EP - 1084

JO - Chinese Journal of Pharmacology and Toxicology

JF - Chinese Journal of Pharmacology and Toxicology

IS - 12

ER -

Research advances in relationship between chemokine receptor-4/chemokine ligand-12 axis and development of gastric cancer

Abstract

Keywords

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