Requirement for BMP signaling in interdigital apoptosis and scale formation

H. Zou, L. Niswander

Research output: Contribution to journalArticlepeer-review

512 Scopus citations


Interdigital cell death leads to regression of soft tissue between embryonic digits in many vertebrates. Although the signals that regulate interdigital apoptosis are not known, BMPs - signaling molecules of the transforming growth factor-β superfamily - are expressed interdigitally. A dominant negative type I BMP receptor (dnBMPR-IB) was used here to block BMP signaling. Expression of dnBMPR in chicken embryonic hind limbs greatly reduced interdigital apoptosis and resulted in webbed feet. In addition, scales were transformed into feathers. The similarity of the webbing to webbed duck feet led to studies that indicate that BMPs are not expressed in the duck interdigit. These results indicate BMP signaling actively mediates cell death in the embryonic limb.

Original languageEnglish
Pages (from-to)738-741
Number of pages4
Issue number5262
StatePublished - 3 May 1996
Externally publishedYes


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