Reproducible novel transcriptional differences between psoriatic lesional and non-lesional skin show increased inflammation and metabolism

Daniel J. Aires, Graham Rockwell, Alan Menter, Colton Nielson, Jo Wick, Stephanie Sedivy, Ossamma Tawfik, Anne Bowcock, Animesh A. Sinha

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Psoriasis is a common but complex chronic inflammatory skin Disease. Array-based studies can help identify therapeutic targets. Objective: To reproducibly assess single-gene transcriptional changes in psoriatic skin. Methods: We evaluated 210 top candidate genes from a first psoriasis study group (population 1), and then confirmed differential expression in a second independent psoriasis study group (population 2). Results: One hundred and thirty-eight differentially expressed genes were replicated in the 2 studies, of which 57 have not previously been reported as associated with psoriasis. This is significantly greater than the 10 expected false positives. Lesional skin vs uninvolved areas showed inflammatory and cell regulation changes. Conclusion: Previously undescribed psoriasis-associated genes revealed in this study may provide potential future targets for development and assessment of novel therapeutic agents for psoriasis.

Original languageEnglish
Pages (from-to)794-800
Number of pages7
JournalJournal of Drugs in Dermatology
Volume14
Issue number8
StatePublished - Aug 2015
Externally publishedYes

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