Reproducibility of retinal thickness measurements in normal eyes using optical coherence tomography

Matthias Baumann, Ronald C. Gentile, Jeffrey M. Liebmann, Robert Ritch

Research output: Contribution to journalArticlepeer-review

136 Scopus citations

Abstract

BACKGROUND AND OBJECTIVE: To determine the reproducibility of retinal thickness measurements in normal eyes using optical coherence tomography (OCT). PATIENTS AND METHODS: Multiple 3.20-mm vertical cross-sectional images through the center of fixation of consecutive patients with normal results on ocular examinations were obtained. Each image was divided into seven 320-μm segments. Regional retinal thicknesses for each section were measured using both the manually assisted (requiting observer localization of reflectivity peaks) and the automated modes (observer-independent measurement) of the computer software. RESULTS: Eighteen right eyes were studied. The mean coefficient of variation was less than 10% for all locations using the manually assisted method (average standard deviation less than 17 μm [range 9 to 16 μm]). The automated method was less reliable, with a coefficient of variation greater than 10% for locations within 500 μm of fixation. Automated measurements at fixation were the least reproducible because of poor internal limiting membrane reflectivity. CONCLUSION: OCT is capable of reproducible measurement of retinal thickness in normal eyes. Computer- driven, automated measurement of retinal thickness within 500 μm of fixation need to be refined and its reproducibility reassessed in this region.

Original languageEnglish
Pages (from-to)280-285
Number of pages6
JournalOphthalmic Surgery and Lasers
Volume29
Issue number4
StatePublished - Apr 1998

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