Repositioning of Tak-475 in mevalonate kinase disease: Translating theory into practice

Keyphrases

• Mevalonate Kinase 100%
• Mevalonate Kinase Deficiency 100%
• Theory into Practice 100%
• Inflammatory Diseases 28%
• Isoprenoids 28%
• Quality of Life 14%
• Inflammation 14%
• Metabolic Disease 14%
• Clinical Trials 14%
• Inflammatory Cytokines 14%
• Autosomal Recessive 14%
• Interleukin-1β 14%
• Safety Profile 14%
• Multisystem Inflammatory Syndrome in children (MIS-C) 14%
• Metabolic Syndrome 14%
• Clinical Symptoms 14%
• New Therapies 14%
• Protein Metabolism 14%
• Inflammatory Stimuli 14%
• Nervous System 14%
• Cholesterol-lowering Agents 14%
• Biologic Therapy 14%
• Sterols 14%
• Good Safety 14%
• Intended Use 14%
• Cellular Models 14%
• Orphan Drugs 14%
• Altered Metabolism 14%
• Mevalonate 14%
• Prenylation 14%
• Similar Action 14%
• Squalene Synthase 14%
• Mevalonate Pathway 14%
• MVK Gene 14%
• Zaragozic Acid 14%
• Systematic Inflammation 14%
• Lapaquistat Acetate 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Disease 100%
• Mevalonate Kinase Deficiency 100%
• Mevalonate Kinase 100%
• Lapaquistat 100%
• Inflammation 42%
• Inflammatory Disease 28%
• Mevalonic Acid 28%
• Isoprenoid 28%
• Symptom 14%
• Metabolic Disorder 14%
• Cytokine 14%
• Clinical Trial 14%
• Metabolic Syndrome X 14%
• Hypocholesterolemic Agent 14%
• Interleukin 1 14%
• Orphan Drug 14%
• Sterol 14%
• Drug Induced Disease 14%
• Squalene Synthase 14%

Biochemistry, Genetics and Molecular Biology

• Translating (Language) 100%
• Mevalonate Kinase 100%
• Clinical Trial 11%
• Enzyme 11%
• Metabolic Pathway 11%
• Interleukin-1 11%
• Autosomal Recessive Inheritance 11%
• Synthase 11%
• Inflammatory Cytokine 11%
• Sterol 11%
• Prenylation 11%
• Mevalonate Pathway 11%